About GT-CORE
GT-CORE is the Glycosyltransferase Curated Online Resource for Enzymology: a curated, family-organised reference for the CAZy glycosyltransferases, built around the catalytic core of each enzyme — its fold class, its mechanism, and the delimited catalytic-domain sequence.
Scope
Glycosyltransferases catalyse the transfer of a sugar from an activated donor, most often a nucleotide sugar, to a specific acceptor: a growing glycan chain, a protein or lipid aglycone, or a small molecule. The CAZy classification groups them into families by sequence similarity, which correlates with fold and catalytic mechanism rather than with substrate specificity — so a single family routinely contains enzymes acting on chemically unrelated acceptors, and conversely a single biosynthetic pathway draws on enzymes from many families.
GT-CORE organises curated records by CAZy family and makes the enzymological attributes that differ within a family — donor, acceptor, localisation, metal dependence, quaternary structure — directly comparable in one table.
Intended use
- Locating a characterised family member to use as a template for construct design, homology modelling or activity comparison.
- Comparing donor and acceptor specificity across the members of one family.
- Retrieving catalytic-domain boundaries for expression construct design.
- Assembling family-level sequence sets for phylogenetic or profile analysis.
Data provenance and limitations
Records are curated from UniProtKB annotation together with structural and enzymological literature. Coverage is deliberately uneven: large families are represented by well-annotated members and, where noted on the family page, a representative subset rather than an exhaustive listing. The UniProt annotation level shown on each record indicates the evidence depth behind that entry; entries below level 4 are flagged and their curated enzymology should be treated as provisional. Absence of a value means the field was not curated, not that the property is absent.
Related resources
Citation
Please cite GT-CORE (Glycosyltransferase Curated Online Resource for Enzymology) and the curated glycosyltransferase dataset it distributes in any publication that makes use of these records.
Site architecture
A static site generated from the source workbook by
tools/build_site.py. See
Curation & Methods for the build model and instructions for
extending coverage to further CAZy families, and the
Data Dictionary for field definitions and coverage.
Contact
Questions should be directed to Dr. Kelley Moremen (moremen@uga.edu).