Home/GT Families/GT1/UGT2B17
UGT2B17
Homo sapiens · UDP-glucuronosyltransferase 2B17 (EC 2.4.1.17)
GT1Model organism · annotation ≥ 4Fold GT-BInverting1 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
|---|
| Gene symbol | UGT2B17 |
|---|
| Synonyms / alternate names | C19-steroid-specific UDP-glucuronosyltransferase |
|---|
| UniProt accession | O75795 |
|---|
| NCBI Gene ID | 7367 |
|---|
| Source species | Homo sapiens |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | UDP-glucuronosyltransferase 2B17 (EC 2.4.1.17) |
|---|
| Subcellular location | Endoplasmic reticulum membrane |
|---|
Structure and mechanism
| Fold type | GT-B |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | 7YAN |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucuronate |
|---|
| Donor CCD code(s) | UGA |
|---|
| Acceptor substrate(s) | - glucuronate acceptor
- 17alpha-estradiol
- 17beta-estradiol
- 17beta-hydroxy-5alpha-androstan-3-one
- testosterone
|
|---|
| Acceptor CCD / GlycoCT | EST Verified PDB CCD code |
|---|
Protein sequences
Full protein sequence
530 aa
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD
Catalytic domain sequence
424 aa
VLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRI
