Home/GT Families/GT1/UGT2B7
UGT2B7
Homo sapiens · UDP-glucuronosyltransferase 2B7 (EC 2.4.1.17)
GT1Model organism · annotation ≥ 4Fold GT-BInverting1 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
|---|
| Gene symbol | UGT2B7 |
|---|
| Synonyms / alternate names | - UGTB2B9
- 3,4-catechol estrogen-specific UDPGT
- UDP-glucuronosyltransferase 2B9
- UDPGTh-2
|
|---|
| UniProt accession | P16662 |
|---|
| NCBI Gene ID | 7364 |
|---|
| Source species | Homo sapiens |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | UDP-glucuronosyltransferase 2B7 (EC 2.4.1.17) |
|---|
| Subcellular location | Endoplasmic reticulum membrane |
|---|
Structure and mechanism
| Fold type | GT-B |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | 2O6L |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-alpha-D-glucuronate
- UDP-alpha-D-glucose
|
|---|
| Donor CCD code(s) | UGA, UPG |
|---|
| Acceptor substrate(s) | - glucuronate acceptor
- a sterol
- 17alpha-estradiol
- 17beta-estradiol
- 2-hydroxy-17beta-estradiol
- 4-hydroxy-17beta-estradiol
- 4-hydroxyestrone
- 16alpha-hydroxyestrone
- 16alpha,17beta-estriol
- 16beta,17beta-estriol
- 16alpha,17alpha-estriol
- epitestosterone
- hyodeoxycholate
- hyocholate
- all-trans-retinoate
- all-trans-4-hydroxyretinoate
- (E)-ferulate
- 8-iso-prostaglandin F2alpha
- 5-epi-5-F2t-IsoP
- (5Z,8Z,11Z,14Z)-eicosatetraenoate
- 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
- 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate
- prostaglandin B1
- mycophenolate
- losartan
- candesartan
- zolasartan
|
|---|
| Acceptor CCD / GlycoCT | EST Verified PDB CCD code |
|---|
Protein sequences
Full protein sequence
529 aa
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
Catalytic domain sequence
424 aa
KVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRI
