Home/GT Families/GT1/Ugt1a2
Ugt1a2
Mus musculus · UDP-glucuronosyltransferase 1-2 (EC 2.4.1.17)
GT1Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
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| Gene symbol | Ugt1a2 |
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| Synonyms / alternate names | - Ugt1
- Bilirubin-specific UDPGT
- UDP-glucuronosyltransferase 1A2
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| UniProt accession | P70691 |
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| NCBI Gene ID | 22236 |
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| Source species | Mus musculus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | UDP-glucuronosyltransferase 1-2 (EC 2.4.1.17) |
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| Subcellular location | - Microsome
- Endoplasmic reticulum membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucuronate |
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| Donor CCD code(s) | UGA |
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| Acceptor substrate(s) | glucuronate acceptor |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
533 aa
MDTGLCVPLRGISGLLLLLCALPWAEGAKVLVLPMEGSQWLSMRDVVRELHARGHQTVVLASEVTVHIKGEDFFTLKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKMLIQQLNSSFFDVILTDPIFPCGAVLAKYLQIPAVFILRSLSCGIEYEATQCPNPSSYIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITPYESLASELLQREVSLVEVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH
Catalytic domain sequence
496 aa
AKVLVLPMEGSQWLSMRDVVRELHARGHQTVVLASEVTVHIKGEDFFTLKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKMLIQQLNSSFFDVILTDPIFPCGAVLAKYLQIPAVFILRSLSCGIEYEATQCPNPSSYIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITPYESLASELLQREVSLVEVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGR
