Home/GT Families/GT1/Ugt1a8
Ugt1a8
Rattus norvegicus · UDP-glucuronosyltransferase 1A8 (EC 2.4.1.17)
GT1Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
|---|
| Gene symbol | Ugt1a8 |
|---|
| Synonyms / alternate names | - Ugt1
- A3
- UDP-glucuronosyltransferase 1-8
|
|---|
| UniProt accession | Q64634 |
|---|
| NCBI Gene ID | not curated |
|---|
| Source species | Rattus norvegicus |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | UDP-glucuronosyltransferase 1A8 (EC 2.4.1.17) |
|---|
| Subcellular location | Endoplasmic reticulum membrane |
|---|
Structure and mechanism
| Fold type | GT-B |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | homooligomer |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucuronate |
|---|
| Donor CCD code(s) | UGA |
|---|
| Acceptor substrate(s) | - glucuronate acceptor
- 17beta-estradiol
- 17alpha-estradiol
- estrone
- 16alpha,17alpha-estriol
- 2-hydroxy-17beta-estradiol
- 2-hydroxyestrone
- 4-hydroxy-17beta-estradiol
- 4-hydroxyestrone
- 2-methoxy-17beta-estradiol
- 2-methoxyestrone
- 4-methoxy-17beta-estradiol
- 4-methoxyestrone
- 17beta-hydroxy-5alpha-androstan-3-one
- 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate)
- prunetin
- (E)-ferulate
- candesartan
- mycophenolate
|
|---|
| Acceptor CCD / GlycoCT | EST Verified PDB CCD code |
|---|
Protein sequences
Full protein sequence
530 aa
MAPSGCPPSLPLCVCLFLASGFAQAGRLLVVPMDGSHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGKSLNFTVKLLLVLNTLEDLNYHFKFFAHNQWKTQEVGMFSLLKHSGKGFFELLFSHCRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLILAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSYVPRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVLQTPVTMRDLFSPVSIWMFRTDFVLEFPRPMMPNMVYIGGINCHQGKPLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTLLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH
Catalytic domain sequence
495 aa
GRLLVVPMDGSHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGKSLNFTVKLLLVLNTLEDLNYHFKFFAHNQWKTQEVGMFSLLKHSGKGFFELLFSHCRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLILAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSYVPRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVLQTPVTMRDLFSPVSIWMFRTDFVLEFPRPMMPNMVYIGGINCHQGKPLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTLLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGR
