GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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Ugt1a9

Mus musculus · UDP-glucuronosyltransferase 1A9 (EC 2.4.1.17)

GT1Non-model organism · annotation 4–5Fold GT-BInverting

External resources

UniProt Q62452AlphaFold modelInterPro domainsNCBI Gene 394434CAZy GT1

Identification and annotation

CAZy familyGT1 · CAZy entry
Gene symbolUgt1a9
Synonyms / alternate names
  • Ugt1
  • Ugt1a12
  • UDP-glucuronosyltransferase 1-7
  • UDP-glucuronosyltransferase 1-9
  • UGT1A12
  • UGTP4
UniProt accessionQ62452
NCBI Gene ID394434
Source speciesMus musculus
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionUDP-glucuronosyltransferase 1A9 (EC 2.4.1.17)
Subcellular locationEndoplasmic reticulum membrane

Structure and mechanism

Fold typeGT-B
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statehomodimer
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorUDP-alpha-D-glucuronate
Donor CCD code(s)UGA
Acceptor substrate(s)
  • glucuronate acceptor
  • 2-hydroxy-17beta-estradiol
  • 4-hydroxy-17beta-estradiol
  • 2-hydroxyestrone
  • 4-hydroxyestrone
  • prunetin
  • 8-iso-prostaglandin F2alpha
  • 5-epi-5-F2t-IsoP
  • (5Z,8Z,11Z,14Z)-eicosatetraenoate
  • 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
  • prostaglandin B1
  • (E)-ferulate
  • candesartan
  • SN-38
  • mycophenolate
Acceptor CCD / GlycoCTEST Verified PDB CCD code

Protein sequences

Full protein sequence

528 aa 
MAPVAFPTSFFLCLLLASGLAQAGRLLVVPMDGSHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCTVKTYSISHTLEDLDREFKYLSYTQWKTPEHSIRSFLTGSARGFFELTFSHCRSLFNDKKLVEYLKQRFFDAVFLDPFDVCGLIVAKYFSLPSVIFARGVFCDYLEEGAQCPSLPSYVPRLFSKYTDTMTFKERVWNHLIYIEEHAFCSYFLRTAVEVASEILQTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQKKSLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH

Catalytic domain sequence

495 aa 
GRLLVVPMDGSHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCTVKTYSISHTLEDLDREFKYLSYTQWKTPEHSIRSFLTGSARGFFELTFSHCRSLFNDKKLVEYLKQRFFDAVFLDPFDVCGLIVAKYFSLPSVIFARGVFCDYLEEGAQCPSLPSYVPRLFSKYTDTMTFKERVWNHLIYIEEHAFCSYFLRTAVEVASEILQTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQKKSLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGR
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