Home/GT Families/GT1/Ugt2a2
Ugt2a2
Mus musculus · UDP-glucuronosyltransferase 2A2 (EC 2.4.1.17)
GT1Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
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| Gene symbol | Ugt2a2 |
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| Synonyms / alternate names | not curated |
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| UniProt accession | Q6PDD0 |
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| NCBI Gene ID | 552899 |
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| Source species | Mus musculus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | UDP-glucuronosyltransferase 2A2 (EC 2.4.1.17) |
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| Subcellular location | Membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucuronate |
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| Donor CCD code(s) | UGA |
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| Acceptor substrate(s) | - glucuronate acceptor
- 17alpha-estradiol
- 17beta-estradiol
- chenodeoxycholate
- lithocholate
- deoxycholate
- hyocholate
- hyodeoxycholate
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| Acceptor CCD / GlycoCT | EST Verified PDB CCD code |
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Protein sequences
Full protein sequence
528 aa
MIKKVLQLLIFHLTLAEIVLSGNVVVWPTDGSHWLNIKILLEELVQRNHSVTVLAPSETLFINSRLDAFINFEEIPVSYTKSKIDEIIEHMIALWLDHRPTPLTMWTFYKELGNLLATFYTTNKQMCDGVLNNPTVMERLQKGGFDVLLADPVTMCGELVALKLGIPFVYTLRFSPAFTVERHCGKIPAPISYVPAALSELTDQMSFGERVKNIISYSLQDYIFKTYWGEWNSYYSKVLGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQTSGEHGIVVFSLGSMVKNLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACVASAILLVAKCCLFIFQKVGKTGKKKKRD
Catalytic domain sequence
503 aa
GNVVVWPTDGSHWLNIKILLEELVQRNHSVTVLAPSETLFINSRLDAFINFEEIPVSYTKSKIDEIIEHMIALWLDHRPTPLTMWTFYKELGNLLATFYTTNKQMCDGVLNNPTVMERLQKGGFDVLLADPVTMCGELVALKLGIPFVYTLRFSPAFTVERHCGKIPAPISYVPAALSELTDQMSFGERVKNIISYSLQDYIFKTYWGEWNSYYSKVLGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQTSGEHGIVVFSLGSMVKNLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACVASAILLVAKCCLFIFQKVGKTGKK
