Home/GT Families/GT1/Ugt2b7
Ugt2b7
Rattus norvegicus · UDP-glucuronosyltransferase 2B7 (EC 2.4.1.17)
GT1Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
|---|
| Gene symbol | Ugt2b7 |
|---|
| Synonyms / alternate names | |
|---|
| UniProt accession | Q62789 |
|---|
| NCBI Gene ID | 286989 |
|---|
| Source species | Rattus norvegicus |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | UDP-glucuronosyltransferase 2B7 (EC 2.4.1.17) |
|---|
| Subcellular location | Endoplasmic reticulum membrane |
|---|
Structure and mechanism
| Fold type | GT-B |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucuronate |
|---|
| Donor CCD code(s) | UGA |
|---|
| Acceptor substrate(s) | - glucuronate acceptor
- 17alpha-estradiol
- 17beta-estradiol
- 2-hydroxy-17beta-estradiol
- 4-hydroxy-17beta-estradiol
- 4-hydroxyestrone
- 16alpha-hydroxyestrone
- 16alpha,17beta-estriol
- 16beta,17beta-estriol
- 16alpha,17alpha-estriol
- epitestosterone
- hyodeoxycholate
- hyocholate
- all-trans-retinoate
- all-trans-4-hydroxyretinoate
- (E)-ferulate
- 8-iso-prostaglandin F2alpha
- 5-epi-5-F2t-IsoP
- (5Z,8Z,11Z,14Z)-eicosatetraenoate
- 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
- 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate
- prostaglandin B1
- mycophenolate
- losartan
- candesartan
- zolasartan
|
|---|
| Acceptor CCD / GlycoCT | EST Verified PDB CCD code |
|---|
Protein sequences
Full protein sequence
530 aa
MPQKWISALLLLQISFCFRSGNCGKVLVWPLEYSHWMNLKIILDELVQRGHEVTVLRPSSSVSLDPKKASGLVYETSPTTSNNDEVEKSFYPVGDMWTYDVPKYTCLRYYPSLNKMFGQFSDLWLQLCREVVSNKELIAKLKESQFDVVLSDAVGPCGELIAEILQLPFVYSLRFATAPGIEKYSAGQPFPPSYVPIILSGFSGQMTFMERVENMLCLLYFDSWFESFPAKDWDPFFSEILGRPTTMVDTMKKAEIWLIRSYWDLEFPRPSLPNIEFVGGLHCQPAKPLPKEMEDFAQSSGEHGVWVFSLGSMIRNITQERANTIASALAQIPQKVFWRFEGKKPDTLGPNTRVFKWIPQNDLLGHPKTKAFVTHGGANGIYESIHYGIPPMVGIPLFAEQRDNVAHMVAKGAAVSIDFHTMSSSDLLNALKAVINNPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLALVSVHSLDVIGFLLACVLAIVLLAVKCCLFLYRFFVKVAKNKRD
Catalytic domain sequence
503 aa
GKVLVWPLEYSHWMNLKIILDELVQRGHEVTVLRPSSSVSLDPKKASGLVYETSPTTSNNDEVEKSFYPVGDMWTYDVPKYTCLRYYPSLNKMFGQFSDLWLQLCREVVSNKELIAKLKESQFDVVLSDAVGPCGELIAEILQLPFVYSLRFATAPGIEKYSAGQPFPPSYVPIILSGFSGQMTFMERVENMLCLLYFDSWFESFPAKDWDPFFSEILGRPTTMVDTMKKAEIWLIRSYWDLEFPRPSLPNIEFVGGLHCQPAKPLPKEMEDFAQSSGEHGVWVFSLGSMIRNITQERANTIASALAQIPQKVFWRFEGKKPDTLGPNTRVFKWIPQNDLLGHPKTKAFVTHGGANGIYESIHYGIPPMVGIPLFAEQRDNVAHMVAKGAAVSIDFHTMSSSDLLNALKAVINNPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLALVSVHSLDVIGFLLACVLAIVLLAVKCCLFLYRFFVKVAK
