Home/GT Families/GT1/eryCIII
eryCIII
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) · 3-alpha-mycarosylerythronolide B desosaminyl transferase (EC 2.4.1.278)
GT1Non-model organism · annotation 4–5Fold GT-BInverting1 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
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| Gene symbol | eryCIII |
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| Synonyms / alternate names | - Desosaminyl transferase EryCIII
- Erythromycin biosynthesis protein CIII
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| UniProt accession | A4F7P3 |
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| NCBI Gene ID | not curated |
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| Source species | Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | 3-alpha-mycarosylerythronolide B desosaminyl transferase (EC 2.4.1.278) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | Heterotetramer composed of EryCII and EryCIII |
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| PDB structures | 2YJN |
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Donor and acceptor specificity
| Sugar nucleotide donor | dTDP-alpha-D-desosamine |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | 3-O-alpha-L-mycarosylerythronolide B |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
421 aa
MRVVFSSMASKSHLFGLVPLAWAFRAAGHEVRVVASPALTEDITAAGLTAVPVGTDVDLVDFMTHAGHDIIDYVRSLDFSERDPATLTWEHLLGMQTVLTPTFYALMSPDTLIEGMVSFCRKWRPDLVIWEPLTFAAPIAAAVTGTPHARLLWGPDITTRARQNFLGLLPDQPEEHREDPLAEWLTWTLEKYGGPAFDEEVVVGQWTIDPAPAAIRLDTGLKTVGMRYVDYNGPSVVPEWLHDEPERRRVCLTLGISSRENSIGQVSIEELLGAVGDVDAEIIATFDAQQLEGVANIPDNVRTVGFVPMHALLPTCAATVHHGGPGSWHTAAIHGVPQVILPDGWDTGVRAQRTQEFGAGIALPVPELTPDQLRESVKRVLDDPAHRAGAARMRDDMLAEPSPAEVVGICEELAAGRREPR
Catalytic domain sequence
407 aa
MRVVFSSMASKSHLFGLVPLAWAFRAAGHEVRVVASPALTEDITAAGLTAVPVGTDVDLVDFMTHAGHDIIDYVRSLDFSERDPATLTWEHLLGMQTVLTPTFYALMSPDTLIEGMVSFCRKWRPDLVIWEPLTFAAPIAAAVTGTPHARLLWGPDITTRARQNFLGLLPDQPEEHREDPLAEWLTWTLEKYGGPAFDEEVVVGQWTIDPAPAAIRLDTGLKTVGMRYVDYNGPSVVPEWLHDEPERRRVCLTLGISSRENSIGQVSIEELLGAVGDVDAEIIATFDAQQLEGVANIPDNVRTVGFVPMHALLPTCAATVHHGGPGSWHTAAIHGVPQVILPDGWDTGVRAQRTQEFGAGIALPVPELTPDQLRESVKRVLDDPAHRAGAARMRDDMLAEPSPAEVV
