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fsoA
Humicola fuscoatra · Terpene cyclase-glycosyl transferase fusion protein fsoA
GT1Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
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| Gene symbol | fsoA |
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| Synonyms / alternate names | Fuscoatroside biosynthesis cluster protein A |
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| UniProt accession | P9WEH1 |
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| NCBI Gene ID | not curated |
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| Source species | Humicola fuscoatra |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Terpene cyclase-glycosyl transferase fusion protein fsoA |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucose |
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| Donor CCD code(s) | UPG |
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| Acceptor substrate(s) | - (S)-2,3-epoxysqualene
- isomotiol
- 2alpha-hydroxyisomotiol
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
1338 aa
MDMAPDELDELRGSAQRALEQAIDFSFSCQQDDGHWVAPVSADATFTAQYVMFKHAIPALNLDISGAEAAALRHWLLGDQNAAEGSWGLAPGLPGNLSTTVEAYLALRLLGVPSSNPALQQARRFVLAHGGISRVRFFTRFFLATFGLFPWSAIPQMPAELILMPKWAPLNIYVLSSWARSTLIPILVVRHHEPLYPLPNAQSDPNSGFLDELWLDPTNKEVPFAPPLWDMFHGRDRDVVKLAFTLGDKALAQIGGLKKGPQRRLALRRCIEWLLEHQEETGDWAGFFPPMHGSVWALLLEGFSLEHDVVKRGLEALERLAVNDESGKWLQSTVSPCWDTALMVKALCDAGLGLGGAEAAKGNRHARVTTAVDWVRSLQLLGPQGDWRVYSRNQRPGGWSFEYNNTWYPDVDDTAVVVMMLVTHDPAAVESNAVEMGIEWILGMQNHDGGWGAFDTNNDALWLHKIPFSDMDSLVDPSTSDVTGRMLECFGMLLTHRKGGLRLRPELSQRLHESAQKALAFLFREQTASGAWWGRWGCNYNYGTTNVLRGLPAFCGDKEVARAALRAVLWLEKCQNKDGGWGETLLSYGHPDLAGKGPSTAAHTAWALDALLRFRPASDPALQKGVQWLVSNQVPKTEEKRHWASWPSDLYVGTGFPNVLYLGYPFYHHHFAISALARFLDRTDEPDQDRDLPLLMTRHVVTTLTRHDILLMVLGSRGDIDVFLSIAGKLAKNRHRVRVATHPAHQQLVEAHGFEFYDVGGGPDEFAQVLGREPNLLWSVIRGDLGRLRQSLCRTFARFWEAGYGSNNTRNARNADPKANGIADSRPFVADLIVSTPATTVHVHAAETLRAPLVLIAAQPTLPTREFPHVFTMNKPRYSPGSWWNYATFFFLELLNWLAMGSFVNKLRVHTYKMKPLCWVWATQDFLTAKIPLVCLWSSNVVPRPPEWHDEVMVAGSTTLAQVDQFTPPLSLLEFLNADMEKPTVVVSFGSMFIADPPALISAIASAAAQVRAKVVICRSWRWKLESSLASLPSHTYVADAIPHSWLLPRVDGFVHHGGAGHTAAGLRAGVPMLITPFFLDQHFWAAKVHNLGLGPEPLEIMMRAGTVAGIQTHQGKMQFAQSMQDLLSGQYSRRCAEMSERVRAETDGANVAADVIERELGSALARSGHCAVVPALPAQWQHAESGLALCGVAAASLVTSGMLDWDDLDAITRIDWIARRQKDPKSRLHAICFVADWLGHAFGMLLAVAGWLLQLVGDVRSVGRVKPHHNTDPIRLAMMERSMFDLNFAKQGLAEAELKGGAFEELLARRWRAAVAAAFERRMERTGNMLLGEGCQG
Catalytic domain sequence
451 aa
ILLMVLGSRGDIDVFLSIAGKLAKNRHRVRVATHPAHQQLVEAHGFEFYDVGGGPDEFAQVLGREPNLLWSVIRGDLGRLRQSLCRTFARFWEAGYGSNNTRNARNADPKANGIADSRPFVADLIVSTPATTVHVHAAETLRAPLVLIAAQPTLPTREFPHVFTMNKPRYSPGSWWNYATFFFLELLNWLAMGSFVNKLRVHTYKMKPLCWVWATQDFLTAKIPLVCLWSSNVVPRPPEWHDEVMVAGSTTLAQVDQFTPPLSLLEFLNADMEKPTVVVSFGSMFIADPPALISAIASAAAQVRAKVVICRSWRWKLESSLASLPSHTYVADAIPHSWLLPRVDGFVHHGGAGHTAAGLRAGVPMLITPFFLDQHFWAAKVHNLGLGPEPLEIMMRAGTVAGIQTHQGKMQFAQSMQDLLSGQYSRRCAEMSERVRAETDGANVAADVIER
