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ugt8
Danio rerio · 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.47)
GT1Model organism · annotation ≥ 4Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT1 · CAZy entry |
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| Gene symbol | ugt8 |
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| Synonyms / alternate names | - Ceramide UDP-galactosyltransferase
- Cerebroside synthase
- UDP-galactose-ceramide galactosyltransferase
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| UniProt accession | Q1ECX6 |
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| NCBI Gene ID | 553508 |
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| Source species | Danio rerio |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.47) |
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| Subcellular location | - Endoplasmic reticulum
- Membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
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| Donor CCD code(s) | GDU |
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| Acceptor substrate(s) | - N-(2-hydroxy-hexanoyl)-sphing-4-enine
- N-(2-hydroxy-hexanoyl)-sphinganine
- an N-acyl-sphingoid base
- an N-acylsphing-4-enine
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
541 aa
MKAFFVLATLLWCLATSLSRAAKIVVVPPIMFESHLYIFKTLASALHAEGHDTVFLVSEGREIPPSNHYRLQRYPGIFNSTSADDFLQSKVRNIFSGRLTALELFDILDHYSQNCDAVVGSTSVMEQLKREHFDLLLVDPNEMCGFVIAHILGVQYAVFSTGLWYPAEVGAPAPLSYVPEFNSLLTDHMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRKYNIQPSVSMHDLVQNSRLWMLCTDMALEFPRPTLPHVVYVGGILTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGVKYLSDDIAQKLAGALSRLPQRVIWRFSGVPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDVAMVIGVCLLLTGYCLYRIVKCIQSRLGRGSSPGEKVNGHCHNGIPNGKHKRNGHVKSMEKKLK
Catalytic domain sequence
427 aa
AKIVVVPPIMFESHLYIFKTLASALHAEGHDTVFLVSEGREIPPSNHYRLQRYPGIFNSTSADDFLQSKVRNIFSGRLTALELFDILDHYSQNCDAVVGSTSVMEQLKREHFDLLLVDPNEMCGFVIAHILGVQYAVFSTGLWYPAEVGAPAPLSYVPEFNSLLTDHMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRKYNIQPSVSMHDLVQNSRLWMLCTDMALEFPRPTLPHVVYVGGILTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGVKYLSDDIAQKLAGALSRLPQRVIWRFSGVPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIHKDQPGHPVSRAVYW
