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Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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FUT3

Pan troglodytes · 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65; 2.4.1.152; 2.4.1.-)

GT10Non-model organism · annotation 4–5Fold GT-BInverting

External resources

UniProt O19058AlphaFold modelInterPro domainsNCBI Gene 493975CAZy GT10

Identification and annotation

CAZy familyGT10 · CAZy entry
Gene symbolFUT3
Synonyms / alternate names
  • 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
  • Alpha-3-fucosyltransferase FUT3
  • Alpha-3/4-fucosyltransferase
  • Blood group Lewis alpha-4-fucosyltransferase
  • Fucosyltransferase 3
  • Fucosyltransferase III
UniProt accessionO19058
NCBI Gene ID493975
Source speciesPan troglodytes
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme function3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65; 2.4.1.152; 2.4.1.-)
Subcellular location
  • Golgi apparatus
  • Golgi stack membrane

Structure and mechanism

Fold typeGT-B
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorGDP-beta-L-fucose
Donor CCD code(s)GFB
Acceptor substrate(s)
  • a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative
  • an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
  • a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
  • an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative
  • Lc4Cer
  • a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))
  • N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
  • N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine
  • beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
  • alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc
  • alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc
  • beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
  • lactose
  • an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative
Acceptor CCD / GlycoCTRES 1b:b-dgal-HEX-1:5 2b:x-dglc-HEX-1:5 LIN 1:1o(4+1)2d

Protein sequences

Full protein sequence

372 aa 
MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPSGSSRQDTTPTRPTLLILLWTWPFHIPVALSRCSEMVPGAADCHITADRKVYPQADAVIVHHWDIMYNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKLDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTMRSIAAWFT

Catalytic domain sequence

173 aa 
SAKTELVAWAVSNWKLDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTMRSIAAW
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