GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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FUT5

Pongo pygmaeus · 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (EC 2.4.1.152; 2.4.1.65)

GT10Non-model organism · annotation 4–5Fold GT-BInverting

External resources

UniProt Q8HYJ4AlphaFold modelInterPro domainsCAZy GT10

Identification and annotation

CAZy familyGT10 · CAZy entry
Gene symbolFUT5
Synonyms / alternate names
  • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5
  • Fucosyltransferase 5
  • Fucosyltransferase V
  • Galactoside 3-L-fucosyltransferase
UniProt accessionQ8HYJ4
NCBI Gene IDnot curated
Source speciesPongo pygmaeus
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme function4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (EC 2.4.1.152; 2.4.1.65)
Subcellular location
  • Golgi apparatus
  • Golgi stack membrane

Structure and mechanism

Fold typeGT-B
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorGDP-beta-L-fucose
Donor CCD code(s)GFB
Acceptor substrate(s)
  • a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative
  • an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
  • an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative
  • a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
  • a neolactoside nLc4Cer
  • a neolactoside nLc6Cer
  • a neolactoside nLc6Cer(d18:1(4E))
  • a neolactoside nLc4Cer(d18:1(4E))
  • a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer
  • beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
  • N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
  • alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc
  • an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

374 aa 
MDPLGPAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPNGSRCQDSTATPAHPTLLILLWTWPFTTPIALPRCSEMVPGVADCNITADSSVYPQADAVIVHHWDIMYNPGANLPPPTRPQGQRWIWFSLESPSYCRHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSVHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT

Catalytic domain sequence

173 aa 
SAKTELVAWAVSNWKPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSVHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAW
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