GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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FUT6

Homo sapiens · 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (EC 2.4.1.152)

GT10Model organism · annotation ≥ 4Fold GT-BInverting

External resources

UniProt P51993AlphaFold modelInterPro domainsNCBI Gene 2528CAZy GT10

Identification and annotation

CAZy familyGT10 · CAZy entry
Gene symbolFUT6
Synonyms / alternate names
  • FCT3A
  • Fucosyltransferase 6
  • Fucosyltransferase VI
  • Galactoside 3-L-fucosyltransferase
UniProt accessionP51993
NCBI Gene ID2528
Source speciesHomo sapiens
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme function4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (EC 2.4.1.152)
Subcellular location
  • Golgi apparatus, Golgi stack membrane
  • Golgi apparatus
  • Secreted

Structure and mechanism

Fold typeGT-B
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statehomodimer
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorGDP-beta-L-fucose
Donor CCD code(s)GFB
Acceptor substrate(s)
  • a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
  • an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
  • an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative
  • a neolactoside nLc6Cer
  • a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer
  • beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
  • N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
  • lactose
  • alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc
  • a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative
Acceptor CCD / GlycoCTRES 1b:b-dgal-HEX-1:5 2b:x-dglc-HEX-1:5 LIN 1:1o(4+1)2d

Protein sequences

Full protein sequence

359 aa 
MDPLGPAKPQWSWRCCLTTLLFQLLMAVCFFSYLRVSQDDPTVYPNGSRFPDSTGTPAHSIPLILLWTWPFNKPIALPRCSEMVPGTADCNITADRKVYPQADAVIVHHREVMYNPSAQLPRSPRRQGQRWIWFSMESPSHCWQLKAMDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQTRGIAAWFT

Catalytic domain sequence

166 aa 
SAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQT
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