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FUT9
Cricetulus griseus · 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152)
GT10Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT10 · CAZy entry |
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| Gene symbol | FUT9 |
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| Synonyms / alternate names | - Fucosyltransferase 9
- Fucosyltransferase IX
- Galactoside 3-L-fucosyltransferase
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| UniProt accession | Q9JIG1 |
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| NCBI Gene ID | 100689036 |
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| Source species | Cricetulus griseus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152) |
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| Subcellular location | - Golgi apparatus, trans-Golgi network membrane
- Golgi apparatus membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | - a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative
- alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
- alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
- a neolactoside nLc4Cer
- an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc
- an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
359 aa
MTSTSKGILRPFLIVCVILACFMACLLIYIKPTNSWVFSPMESASSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNEKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
Catalytic domain sequence
174 aa
PSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNEKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKW
