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FUTeu2
Eulemur fulvus · 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (EC 2.4.1.65)
GT10Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT10 · CAZy entry |
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| Gene symbol | FUTeu2 |
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| Synonyms / alternate names | - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5
- Fucosyltransferase 5
- Fucosyltransferase V
- Galactoside 3-L-fucosyltransferase
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| UniProt accession | Q8WMU9 |
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| NCBI Gene ID | not curated |
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| Source species | Eulemur fulvus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (EC 2.4.1.65) |
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| Subcellular location | - Endomembrane system
- Membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | - N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
- a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative
- a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer
- a neolactoside nLc4Cer(d18:1(4E))
- a neolactoside nLc6Cer
- a neolactoside nLc6Cer(d18:1(4E))
- alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc
- an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative
- an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative
- beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
180 aa
MDPLGPAKRQCPWRPCLAGLLLQLLVAVCLFSYQRVSQDGPVGSPRPGSTALESVTSAPSGSTGTMSTNGSRCQATSGSPAHPPLLILLWTWPFNHPVSLSRCSEMVPGAADCHLTANRSVYPRADGVIVHHRDVMYSPTTKLPPSPRPPGQRWVWLNMESPTNSWHLKAMDGHFNLTMS
Catalytic domain sequence
96 aa
LLILLWTWPFNHPVSLSRCSEMVPGAADCHLTANRSVYPRADGVIVHHRDVMYSPTTKLPPSPRPPGQRWVWLNMESPTNSWHLKAMDGHFNLTMS
