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FucTC
Anopheles gambiae · Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152)
GT10Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT10 · CAZy entry |
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| Gene symbol | FucTC |
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| Synonyms / alternate names | - 1271890
- Fucosyltransferase C
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| UniProt accession | Q7QF91 |
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| NCBI Gene ID | not curated |
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| Source species | Anopheles gambiae |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) |
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| Subcellular location | - Golgi apparatus
- Golgi stack membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mg2+, Ca2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
405 aa
MVALLDRKMQLKHVLLFGTVVLLCCLYLVYDKCLLATINSYQVLDDHNRARAARIEQEVGGDRRTRYILLYTSFFSERWWGLLAETLGPDYFAYKHCPATDCVLTSNRQLLRAVADYDAVVFHVATGWDGPLPAVRSPHQLYVAALMESPAHTKHSLALDGSYFNWTMTYRLDSDVLFNYRNVVDLESGEVIGPAVRPSWRNGFYEYGNASLVELVQRKRKAAAQFVSHCGALSGRDRLVQALQSAGLEVDVYGSCGTLNCPRGKPECSQMLDTVYWFYLSFENSLCVDYVTEKLYNALEHHIVPVVFGGADYNRFMPPGSYIDAQAFRTATELVEHLRYLMDNPAEYVRYFWWKQHYALGDTNQYCDLCQRLHSVSARERVQYYRDIKAWWYDDACTARSKIEF
Catalytic domain sequence
175 aa
QRKRKAAAQFVSHCGALSGRDRLVQALQSAGLEVDVYGSCGTLNCPRGKPECSQMLDTVYWFYLSFENSLCVDYVTEKLYNALEHHIVPVVFGGADYNRFMPPGSYIDAQAFRTATELVEHLRYLMDNPAEYVRYFWWKQHYALGDTNQYCDLCQRLHSVSARERVQYYRDIKAW
