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fucT
Helicobacter pylori · Alpha-(1,3)-fucosyltransferase FucT (EC 2.4.1.152)
GT10Non-model organism · annotation 4–5Fold GT-BInverting4 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT10 · CAZy entry |
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| Gene symbol | fucT |
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| Synonyms / alternate names | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase |
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| UniProt accession | O30511 |
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| NCBI Gene ID | not curated |
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| Source species | Helicobacter pylori |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Alpha-(1,3)-fucosyltransferase FucT (EC 2.4.1.152) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | 2NZW, 2NZX, 2NZY, 5ZOI |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
478 aa
MFQPLLDAYVESASIEKMASKSPPPLKIAVANWWGDEEIKEFKNSVLYFILSQRYTITLHQNPNEFSDLVFGNPLGSARKILSYQNAKRVFYTGENESPNFNLFDYAIGFDELDFNDRYLRMPLYYDRLHHKAESVNDTTAPYKLKDNSLYALKKPSHCFKEKHPNLCAVVNDESDPLKRGFASFVASNPNAPIRNAFYDALNSIEPVTGGGSVRNTLGYNVKNKNEFLSQYKFNLCFENTQGYGYVTEKIIDAYFSHTIPIYWGSPSVAKDFNPKSFVNVHDFKNFDEAIDYIKYLHTHKNAYLDMLYENPLNTLDGKAYFYQNLSFKKILAFFKTILENDTIYHDNPFIFCRDLNEPLVTIDDLRVNYDDLRVNYDDLRINYDDLRVNYDDLRINYDDLRVNYDDLRVNYDDLRINYDDLRVNYDDLRVNYERLLSKATPLLELSQNTTSKIYRKAYQKSLPLLRAIRRWVKKLGL
Catalytic domain sequence
125 aa
FASFVASNPNAPIRNAFYDALNSIEPVTGGGSVRNTLGYNVKNKNEFLSQYKFNLCFENTQGYGYVTEKIIDAYFSHTIPIYWGSPSVAKDFNPKSFVNVHDFKNFDEAIDYIKYLHTHKNAYLD
