Home/GT Families/GT10/fut9b.2
fut9b.2
Danio rerio · Fucosyltransferase (EC 2.4.1.-)
GT10Model organism · annotation ≥ 4Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT10 · CAZy entry |
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| Gene symbol | fut9b.2 |
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| Synonyms / alternate names | not curated |
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| UniProt accession | A8E521 |
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| NCBI Gene ID | 100126121 |
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| Source species | Danio rerio |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Fucosyltransferase (EC 2.4.1.-) |
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| Subcellular location | - Golgi apparatus, Golgi stack membrane
- Golgi apparatus, trans-Golgi network membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | - a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- a neolactoside nLc4Cer
- alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
- alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide
- an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative
- an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative
- beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
369 aa
MSRTNGLSLCRLGIVVALAGIVCLSIMFFWFPPSPTCPPQFVQRVQHYESSSAKSSNSLTDTAENKPILLMWFWPENFRFDLNDCKNIFNIDSCLLTDNRSLYSDADAVLIYHKSISWDLSNLPPSPRPPFQKWIWFHLESPTNTQKKPGLENLFNHTLSYRQDADIFTRLHLTVRKKPADDFVIPKKDKLVCWIVSNNALGTGVGTRNTFYQEFSKHINVTMFGRAYASHLDPKDYYPTLASCKFYLSFENSMHKDYITEKINGPLSVGTVPVVLGPPRKNYENFYPRDAFIHVQDFPDPKSVAEYLLQLDKDEDAYHRYFDWRKYYSATPHLLQQQEFDLPICTACDYIAKHKEYKEIHDLYEWYFN
Catalytic domain sequence
181 aa
PKKDKLVCWIVSNNALGTGVGTRNTFYQEFSKHINVTMFGRAYASHLDPKDYYPTLASCKFYLSFENSMHKDYITEKINGPLSVGTVPVVLGPPRKNYENFYPRDAFIHVQDFPDPKSVAEYLLQLDKDEDAYHRYFDWRKYYSATPHLLQQQEFDLPICTACDYIAKHKEYKEIHDLYEW
