Home/GT Families/GT105/Tmtc3
Tmtc3
Drosophila melanogaster · Protein O-mannosyl-transferase Tmtc3 (EC 2.4.1.109)
GT105Model organism · annotation ≥ 4Fold GT-CInverting
External resources
Identification and annotation
| CAZy family | GT105 · CAZy entry |
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| Gene symbol | Tmtc3 |
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| Synonyms / alternate names | - Transmembrane O-mannosyltransferase targeting cadherins 3
- Transmembrane and tetratricopeptide repeat-containing 3
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| UniProt accession | Q7K4B6 |
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| NCBI Gene ID | 37401 |
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| Source species | Drosophila melanogaster |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Protein O-mannosyl-transferase Tmtc3 (EC 2.4.1.109) |
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| Subcellular location | - Membrane
- Endoplasmic reticulum
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Structure and mechanism
| Fold type | GT-C |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | not curated |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | - a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate
- L-seryl-[protein]
- L-threonyl-[protein]
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
926 aa
MSTNPNPGIHQYAPSTLPREREREGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYEDYDPLEFKLPQDRPTHKSRKRS
Catalytic domain sequence
72 aa
SQLPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLAL
