Home/GT Families/GT109/PGAP4
PGAP4
Homo sapiens · GPI-N-acetylgalactosamine transferase PGAP4 (EC 2.4.1.-)
GT109Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT109 · CAZy entry |
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| Gene symbol | PGAP4 |
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| Synonyms / alternate names | - C9orf125
- TMEM246
- Post-GPI attachment to proteins GalNAc transferase 4
- Post-GPI attachment to proteins factor 4
- Transmembrane protein 246
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| UniProt accession | Q9BRR3 |
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| NCBI Gene ID | 84302 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | GPI-N-acetylgalactosamine transferase PGAP4 (EC 2.4.1.-) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | - [protein]-C-terminal carboxyl phosphoethanolamide-(1-radyl
- 2-octadecanoyl)-GPI(deacylinositol-H7)
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
403 aa
MSTSTSPAAMLLRRLRRLSWGSTAVQLFILTVVTFGLLAPLACHRLLHSYFYLRHWHLNQMSQEFLQQSLKEGEAALHYFEELPSANGSVPIVWQATPRPWLVITIITVDRQPGFHYVLQVVSQFHRLLQQCGPQCEGHQLFLCNVERSVSHFDAKLLSKYVPVANRYEGTEDDYGDDPSTNSFEKEKQDYVYCLESSLQTYNPDYVLMVEDDAVPEEQIFPVLEHLLRARFSEPHLRDALYLKLYHPERLQHYINPEPMRILEWVGVGMLLGPLLTWIYMRFASRPGFSWPVMLFFSLYSMGLVELVGRHYFLELRRLSPSLYSVVPASQCCTPAMLFPAPAARRTLTYLSQVYCHKGFGKDMALYSLLRAKGERAYVVEPNLVKHIGLFSSLRYNFHPSLL
Catalytic domain sequence
285 aa
LVITIITVDRQPGFHYVLQVVSQFHRLLQQCGPQCEGHQLFLCNVERSVSHFDAKLLSKYVPVANRYEGTEDDYGDDPSTNSFEKEKQDYVYCLESSLQTYNPDYVLMVEDDAVPEEQIFPVLEHLLRARFSEPHLRDALYLKLYHPERLQHYINPEPMRILEWVGVGMLLGPLLTWIYMRFASRPGFSWPVMLFFSLYSMGLVELVGRHYFLELRRLSPSLYSVVPASQCCTPAMLFPAPAARRTLTYLSQVYCHKGFGKDMALYSLLRAKGERAYVVEPNLVK
