GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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FUT1

Pan troglodytes · Galactoside alpha-(1,2)-fucosyltransferase 1 (EC 2.4.1.69; 2.4.1.344)

GT11Non-model organism · annotation 4–5Fold GT-BInverting

External resources

UniProt Q9TUD6AlphaFold modelInterPro domainsNCBI Gene 468947CAZy GT11

Identification and annotation

CAZy familyGT11 · CAZy entry
Gene symbolFUT1
Synonyms / alternate names
  • Alpha(1,2)FT 1
  • Fucosyltransferase 1
  • GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
  • Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1
  • Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1
UniProt accessionQ9TUD6
NCBI Gene ID468947
Source speciesPan troglodytes
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionGalactoside alpha-(1,2)-fucosyltransferase 1 (EC 2.4.1.69; 2.4.1.344)
Subcellular location
  • Golgi apparatus
  • Golgi stack membrane

Structure and mechanism

Fold typeGT-B
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorGDP-beta-L-fucose
Donor CCD code(s)GFB
Acceptor substrate(s)
  • a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
  • a ganglioside GA1
  • a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))
  • a neolactoside nLc4Cer(d18:1(4E))
  • a ganglioside GM1
  • beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

366 aa 
MWPPSHRQLCLAFLLVCVLSVISFFLHIHQDSFPHGLGLSILCPDRGLVTPPVAIFCLPGTAMGPNASSSCPQHPASLSGTWTVYPNGRFGNQMGQYATLLALAQLNGRRAFILPAMHAALAPVFRITLPVLAPEADSRTPWRELQLHDWMSEEYADLRDPFLKLSGFPCSWTFFHHLREQIRREFTLHDHLREEAQSVLGQLRLGRTGDRPRTFVGVHVRRGDYLQVMPQRWKGVVGDSAYLRQAMDWFRARHEAPVFVVTSNGMEWCKENIDTSQGDVTFAGDGQEATPWKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFKPEAAFLPEWVGINADLSSLWTLAKP

Catalytic domain sequence

316 aa 
LSILCPDRGLVTPPVAIFCLPGTAMGPNASSSCPQHPASLSGTWTVYPNGRFGNQMGQYATLLALAQLNGRRAFILPAMHAALAPVFRITLPVLAPEADSRTPWRELQLHDWMSEEYADLRDPFLKLSGFPCSWTFFHHLREQIRREFTLHDHLREEAQSVLGQLRLGRTGDRPRTFVGVHVRRGDYLQVMPQRWKGVVGDSAYLRQAMDWFRARHEAPVFVVTSNGMEWCKENIDTSQGDVTFAGDGQEATPWKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFKPEAAFLPEWVGIN
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