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FUT2
Pongo pygmaeus · Galactoside alpha-(1,2)-fucosyltransferase 2 (EC 2.4.1.69; 2.4.1.344)
GT11Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT11 · CAZy entry |
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| Gene symbol | FUT2 |
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| Synonyms / alternate names | - Alpha(1,2)FT 2
- Fucosyltransferase 2
- GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
- Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
- Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
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| UniProt accession | O77487 |
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| NCBI Gene ID | not curated |
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| Source species | Pongo pygmaeus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Galactoside alpha-(1,2)-fucosyltransferase 2 (EC 2.4.1.69; 2.4.1.344) |
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| Subcellular location | - Golgi apparatus
- Golgi stack membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | - a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative
- a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- a neolactoside nLc4Cer
- a neolactoside nLc4Cer(d18:1(4E))
- a ganglioside GM1
- a ganglioside GA1
- Lc4Cer
- a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))
- a ganglioside GD1b
- a ganglioside GM1 (d18:1(4E))
- a globoside GalGb4Cer (d18:1(4E))
- a lactoside III(4)-a-Fuc-Lc4Cer
- beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
343 aa
MLVVQMPFSFPVAHFILFVFTVSTIFHIQQRLAKIQAMWELPEQIPVLASTSKALGPSQLRGIWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSTTASRIPWQNYHLNDWMEEKYRHIPGEYVRLTGYPCSWTFYHHLRHEILQEFTLHDHVREEAQKFLRGLQVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSPIFVVTSNGMAWCQENIDTSHSDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH
Catalytic domain sequence
314 aa
TVSTIFHIQQRLAKIQAMWELPEQIPVLASTSKALGPSQLRGIWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSTTASRIPWQNYHLNDWMEEKYRHIPGEYVRLTGYPCSWTFYHHLRHEILQEFTLHDHVREEAQKFLRGLQVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSPIFVVTSNGMAWCQENIDTSHSDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIA
