Home/GT Families/GT11/Sec1
Sec1
Brachylagus idahoensis · L-Fucosyltransferase (EC 2.4.1.-)
GT11Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT11 · CAZy entry |
|---|
| Gene symbol | Sec1 |
|---|
| Synonyms / alternate names | not curated |
|---|
| UniProt accession | A0A0F6RAP2 |
|---|
| NCBI Gene ID | not curated |
|---|
| Source species | Brachylagus idahoensis |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 4 |
|---|
Function and localisation
| Enzyme function | L-Fucosyltransferase (EC 2.4.1.-) |
|---|
| Subcellular location | - Golgi apparatus
- Golgi stack membrane
|
|---|
Structure and mechanism
| Fold type | GT-B |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
|---|
| Donor CCD code(s) | GFB |
|---|
| Acceptor substrate(s) | - Lc4Cer
- a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))
- a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative
- a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- a ganglioside GA1
- a ganglioside GD1b
- a ganglioside GM1 (d18:1(4E))
- a ganglioside GM1
- a globoside GalGb4Cer (d18:1(4E))
- a lactoside III(4)-a-Fuc-Lc4Cer
- a neolactoside nLc4Cer
- a neolactoside nLc4Cer(d18:1(4E))
- beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
284 aa
GMWTINAMGRLGNQMGEYATLYALAKENGRPAYIPAQMHSTLAPIFRISLPVLHSSTASRXPWQNYHLNDWMEERYRHIPAPYVRLTGYPCSWTFYHHLRHEILREFTLHDHVREEAQAFLRGLRVNGSRPSTFVGVHVRRGDYVRXMPQVWKGVVADRGYLEQALDWFRARYRSPVFVVTSNGMAWCRENIDASRGDVVFAGNGLEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTVPDSPFHLVFKPEAAFLPEWVGITANLGRALWSGL
Catalytic domain sequence
272 aa
GMWTINAMGRLGNQMGEYATLYALAKENGRPAYIPAQMHSTLAPIFRISLPVLHSSTASRXPWQNYHLNDWMEERYRHIPAPYVRLTGYPCSWTFYHHLRHEILREFTLHDHVREEAQAFLRGLRVNGSRPSTFVGVHVRRGDYVRXMPQVWKGVVADRGYLEQALDWFRARYRSPVFVVTSNGMAWCRENIDASRGDVVFAGNGLEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTVPDSPFHLVFKPEAAFLPEWVGI
