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Sec1
Mus musculus · Galactoside 2-alpha-L-fucosyltransferase Sec1 (EC 2.4.1.-)
GT11Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT11 · CAZy entry |
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| Gene symbol | Sec1 |
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| Synonyms / alternate names | - Fut3
- Alpha(1,2)FT 3
- GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3
- Secretory blood group protein 1
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| UniProt accession | P97353 |
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| NCBI Gene ID | not curated |
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| Source species | Mus musculus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Galactoside 2-alpha-L-fucosyltransferase Sec1 (EC 2.4.1.-) |
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| Subcellular location | - Golgi apparatus
- Golgi stack membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | a ganglioside GM1 |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
368 aa
MPSDSCLLSLTVLQRLRAICPPLSTFYLFFVIFVVSTIFHCHRRLGLVPAPWASPSLVVFPPRHMPREGMFTIRVKGRLGNQMGEYATLFALARMNGRLAFIPASMHSTLAPIFRISLPVLHSDTAKRIPWQNYHLNDWMEERYRHIPGHYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLQVNGSQPSTFVGVHVRRGDYVRVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSDDMAWCRKSITASRGDVAFAGNGLQGSPAKDIALLMQCNHTVITLGTFGIWAAYLTGGDTVYLANFTQPNSPFHTVFKPEAAYLPEWVGIAADLGQPNTVGSGHASARAPKRHWGALL
Catalytic domain sequence
308 aa
VVSTIFHCHRRLGLVPAPWASPSLVVFPPRHMPREGMFTIRVKGRLGNQMGEYATLFALARMNGRLAFIPASMHSTLAPIFRISLPVLHSDTAKRIPWQNYHLNDWMEERYRHIPGHYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLQVNGSQPSTFVGVHVRRGDYVRVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSDDMAWCRKSITASRGDVAFAGNGLQGSPAKDIALLMQCNHTVITLGTFGIWAAYLTGGDTVYLANFTQPNSPFHTVFKPEAAYLPEWVGIA
