Home/GT Families/GT119/murG
murG
Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399) · UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227)
GT119Non-model organism · annotation 4–5Fold GT-CInverting
External resources
Identification and annotation
| CAZy family | GT119 · CAZy entry |
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| Gene symbol | murG |
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| Synonyms / alternate names | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase |
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| UniProt accession | D2Q0F9 |
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| NCBI Gene ID | not curated |
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| Source species | Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-C |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | - [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate
- beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
- di-trans,octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
788 aa
MTSIVDRPGEKAAENSWLVSLRNLLDRPLTSYHLVVGATGLLMVLGLMMVLSASSVLSYNTTNNQFTIFNRQLIWVGVGLPMAYVASRMTPRHFRMLAYLALLGSTFLLVLTYVPGLGKTVNGNTNWVSFGGPLQIQPSEFAKLALVMWCADLYARKQKLLTQWKHLLIPMVPVCGLVIALIVGQRDLGTSLVLMAIMIGMIWVVGAPTRLFVTAIVVVGAIASYFVATEQHRMDRLTNFVNPFADPSGVGWQAYHALYALSTGSWWGVGIGFSRQKWGNLPEAHTDFIFAVIGEELGLVGSLTVLGLFLTLAYAGVRIATRTTEPFIRYCAAGITIWIMAQTLVNLGAVIGLLPIVGIPLPLLSYGGSALLPTLIAVGMLLSFAKAEPGAQAALKETRRPLLRWMSSWRTPGPSGRENTAGALKAVPSIVLAGGGTAGHTSPLIATADALRRIDPTIEIVALGTERGLETKVVPEAGYRLELIPPVPLPRKPTPALFAVPGKMLSSVSAARKVLDDAKADVLVGFGGYVSTPAYVAAWRRKTPIVVHEGNAVPGIANKFAARYCTDTVITSFPGTDLPHAQYVGLPIRRAISTMDRATLRAEARQFFGLDPDAPTLFVTGGSQGARQLNEAFAGAAADLQAAGIQVLHAIGPKNSLEVEQTGPLPYRVLSYVDRMDYAYAAADLVVCRSGSNTVTEVSGVGLPAIYVPLPHGNGEQRLNAKPVVDVGGGLLVDNSAVTPDWVRATVPQLLHDRERLTAMSTAAQGVIRTDADERLARLILDVVRSAS
Catalytic domain sequence
351 aa
SIVLAGGGTAGHTSPLIATADALRRIDPTIEIVALGTERGLETKVVPEAGYRLELIPPVPLPRKPTPALFAVPGKMLSSVSAARKVLDDAKADVLVGFGGYVSTPAYVAAWRRKTPIVVHEGNAVPGIANKFAARYCTDTVITSFPGTDLPHAQYVGLPIRRAISTMDRATLRAEARQFFGLDPDAPTLFVTGGSQGARQLNEAFAGAAADLQAAGIQVLHAIGPKNSLEVEQTGPLPYRVLSYVDRMDYAYAAADLVVCRSGSNTVTEVSGVGLPAIYVPLPHGNGEQRLNAKPVVDVGGGLLVDNSAVTPDWVRATVPQLLHDRERLTAMSTAAQGVIRTDADERLARL
