Home/GT Families/GT12/B4galnt1
B4galnt1
Rattus norvegicus · Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92; 2.4.1.-)
GT12Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT12 · CAZy entry |
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| Gene symbol | B4galnt1 |
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| Synonyms / alternate names | - Galgt
- Galgt1
- (N-acetylneuraminyl)-galactosylglucosylceramide
- GA2 synthase
- GD2 synthase
- GM2 synthase
- GalNAc-T
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| UniProt accession | Q10468 |
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| NCBI Gene ID | 64828 |
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| Source species | Rattus norvegicus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92; 2.4.1.-) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | - a ganglioside GM3 (d18:1(4E))
- a ganglioside GD3 (d18:1(4E))
- a ganglioside GM3
- a ganglioside GD3
- a ganglioside GD1a
- a ganglioside GT3 (d18:1(4E))
- a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
- a neolactoside IV(3)-alpha-NeuGc-nLc4Cer
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
533 aa
MRLDRRALYALVLLLACASLGLLYASTRDAPGLPNPLALWSPPQGPPRLDLLDLATEPRYAHIPVRIKEQVVGLLAQNNCSCESSGGRFALPFLRQVRAIDFTKAFDAEELRAVSISREQEYQAFLARSRSLADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQEASVQEIYQVNLIASLGTWDVAGEVTGVTLTGEGQSDLTLASPILDKLNRQLQLVTYSSRSYQANTADTVRFSTKGHEVAFTILIRHPPNPRLYPPSSLPQGAQYNISALVTVATKTFLRYDRLRALIASIRRFYPTVTIVIADDSDKPERISDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLEKLVDVLERTPLDLVGGAVREISGYATTYRQLLSVEPGAPGFGNCLRQKQGFHHELAGFPNCVVTDGVVNFFLARTDKVRQVGFDPRLNRVAHLEFFLDGLGSLRVGSCSDVVVDHASKVKLPWTSKDPGAELYARYRYPGSLDQSQVAKHRLLFFKHRLQCMTAE
Catalytic domain sequence
144 aa
RYDRLRALIASIRRFYPTVTIVIADDSDKPERISDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLEKLVDVLERTPLDLVGGAVREISGYATTYRQLLSVEPGAPGFGNCLRQKQGFHHELAGFPNCVV
