XYLT1 (GT14)

XYLT1

Homo sapiens · Xylosyltransferase 1 (EC 2.4.2.26)

GT14Model organism · annotation ≥ 4Fold GT-AInverting9 PDB structure(s)

External resources

UniProt Q86Y38 AlphaFold model InterPro domains NCBI Gene 64131 CAZy GT14 PDB 6EJ7 PDB 6EJ8 PDB 6EJ9 PDB 6EJA PDB 6EJB PDB 6EJC PDB 6EJD PDB 6EJE

Identification and annotation

CAZy family	GT14 · CAZy entry
Gene symbol	XYLT1
Synonyms / alternate names	XT1 Peptide O-xylosyltransferase 1 Xylosyltransferase I
UniProt accession	`Q86Y38`
NCBI Gene ID	`64131`
Source species	Homo sapiens
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Xylosyltransferase 1 (EC 2.4.2.26)
Subcellular location	Golgi apparatus membrane Secreted

Structure and mechanism

Fold type	GT-A
Catalytic mechanism	Inverting
Cation dependence	No
Oligomeric state	monomer
PDB structures	`6EJ7`, `6EJ8`, `6EJ9`, `6EJA`, `6EJB`, `6EJC`, `6EJD`, `6EJE`, `6FOA`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-alpha-D-xylose
Donor CCD code(s)	`UDX`
Acceptor substrate(s)	L-seryl-[protein]
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

959 aa

MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR

Catalytic domain sequence

254 aa

IAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKP