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gly-2
Caenorhabditis elegans · Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155)
GT18Model organism · annotation ≥ 4Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT18 · CAZy entry |
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| Gene symbol | gly-2 |
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| Synonyms / alternate names | - GlcNAc-TV
- Glycosylation-related protein 2
- N-acetylglucosaminyltransferase gly-2
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| UniProt accession | Q9NDH7 |
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| NCBI Gene ID | 172360 |
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| Source species | Caenorhabditis elegans |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
669 aa
MRRRHRCVALLFIFSAFITPLGFFYYTISNESKRYSEESEKNYGYQTLEFTESPEEISVDFDKYSQSECSRFPSNVEIEYPECLNKMKWIKNGWKTHHCYIENHIDGSECSFRYYLSQVENYCPPMEHHGKRKGLAKISPSIRRLLPIFESIPHYMKTRINRLWKKWKEGAHEVMQKYPKSMIERRKLNVLVFIGFLANEQKLNMAKKSDHGGPLGELLQWSDLLATLSVIGHHLEVSTNKNTLRNIVWKYMSRGPCQYVNNFRQQLDIIFTDIMGFNILRQHHRQFLLSNRCRIRLLDSFGTHAEFTTKTYFVQNKKSLSGPFSQRNPWGGHGLDLRQHWTFYPHSDDNTFLGFVVDTEGIDKKNNQMIPSALVYGKEQYMWRDAEKPIDVLKRIVTVHSTVADLDLKDSNISSIFKKVQNHGFLNSEEISQLLDNITIFFGLGFPLEGPAPLEAMAHGAVFINAKFKEPKSRLNYKFLAEKPTLRKWTSQNPYMEKIGEPHVITVDIFNELELEEAIKRAISLKPKHFVPFEFTPAGMLHRVALLLEKQELCDKIAYSKRWPPIDQMKIFRTLNADDSCETICHSKQLLCEPSYFPIINSSPLLRRENLCSSTTSDSSPFAPFNCTIQQSAFLFSCASSPPISFEINRLCPCRDYIPEQHAICKKCL
Catalytic domain sequence
556 aa
CYIENHIDGSECSFRYYLSQVENYCPPMEHHGKRKGLAKISPSIRRLLPIFESIPHYMKTRINRLWKKWKEGAHEVMQKYPKSMIERRKLNVLVFIGFLANEQKLNMAKKSDHGGPLGELLQWSDLLATLSVIGHHLEVSTNKNTLRNIVWKYMSRGPCQYVNNFRQQLDIIFTDIMGFNILRQHHRQFLLSNRCRIRLLDSFGTHAEFTTKTYFVQNKKSLSGPFSQRNPWGGHGLDLRQHWTFYPHSDDNTFLGFVVDTEGIDKKNNQMIPSALVYGKEQYMWRDAEKPIDVLKRIVTVHSTVADLDLKDSNISSIFKKVQNHGFLNSEEISQLLDNITIFFGLGFPLEGPAPLEAMAHGAVFINAKFKEPKSRLNYKFLAEKPTLRKWTSQNPYMEKIGEPHVITVDIFNELELEEAIKRAISLKPKHFVPFEFTPAGMLHRVALLLEKQELCDKIAYSKRWPPIDQMKIFRTLNADDSCETICHSKQLLCEPSYFPIINSSPLLRRENLCSSTTSDSSPFAPFNCTIQQSAFLFSCASSPPISFEINRLCPC
