lpxB (GT19)

lpxB

Escherichia coli (strain K12) · Lipid-A-disaccharide synthase (EC 2.4.1.182)

GT19Model organism · annotation ≥ 4Fold GT-BInverting3 PDB structure(s)

External resources

UniProt P10441 AlphaFold model InterPro domains CAZy GT19 PDB 5W8N PDB 5W8S PDB 5W8X

Identification and annotation

CAZy family	GT19 · CAZy entry
Gene symbol	lpxB
Synonyms / alternate names	pgsB
UniProt accession	`P10441`
NCBI Gene ID	`93777243; 944838`
Source species	Escherichia coli (strain K12)
Taxonomic domain	Bacteria
UniProt annotation level	4

Function and localisation

Enzyme function	Lipid-A-disaccharide synthase (EC 2.4.1.182)
Subcellular location	not curated

Structure and mechanism

Fold type	GT-B
Catalytic mechanism	Inverting
Cation dependence	No
Oligomeric state	not curated
PDB structures	`5W8N`, `5W8S`, `5W8X`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine
Donor CCD code(s)	not curated
Acceptor substrate(s)	2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate a lipid X
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

382 aa

MTEQRPLTIALVAGETSGDILGAGLIRALKEHVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ

Catalytic domain sequence

353 aa

IALVAGETSGDILGAGLIRALKEHVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAEVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFREL