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GCS1
Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) · Ceramide glucosyltransferase (EC 2.4.1.80)
GT21Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT21 · CAZy entry |
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| Gene symbol | GCS1 |
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| Synonyms / alternate names | - GLCT-1
- Glucosylceramide synthase
- UDP-glucose ceramide glucosyltransferase
- UDP-glucose:N-acylsphingosine D-glucosyltransferase
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| UniProt accession | I1RPI4 |
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| NCBI Gene ID | 23553106 |
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| Source species | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Ceramide glucosyltransferase (EC 2.4.1.80) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucose |
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| Donor CCD code(s) | UPG |
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| Acceptor substrate(s) | an N-acylsphing-4-enine |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
528 aa
MYSFIECIAGALFVLGCVVVTLVVIGVRALLYNFRNRPAPPLSSQLGQNAPHVTIIRPVKGLEPRLYDCIAASFRQDYPQDKVSIRLCLEDDTDPAYPVLQKVIEDFPTIDARIMLEKEDHVLSETVNMGPNPKIRNLSRAYREAKGDIVWIIDCNIWMAKGVLGRMVDKLMGYRVGGAAKPYKFVHQLPIVVDLMDFSTSLAAEGRSLLDASPEEDHPTEDLGAEEFPKVMSHGGGRIDEMFMTTSHAKFYSAINTLRAAPCAVGKSNMFRKSQLDQATDAILNPKLDQSKNLPTGVDYFSHNICEDHLIGEALWTTDFPGYKSHGLVWGDIAVQPVSGMSVQAYTARRSRWLRARKYTVLSATILEPFTECFLFATYMSLAMTTIPVLSQNLGIPKTWNATAIAWFTITTLWMLIDYIGYLRLHSGVTMEVDEHTPYFAKGFKNTGGIKRRPFLEFLAAWIGREGLAFPVWAYAVVFGNTVNWRGRLFYIHWDTTVDAVEPREERTREVRTPELERGPSRNKHRVD
Catalytic domain sequence
461 aa
RPAPPLSSQLGQNAPHVTIIRPVKGLEPRLYDCIAASFRQDYPQDKVSIRLCLEDDTDPAYPVLQKVIEDFPTIDARIMLEKEDHVLSETVNMGPNPKIRNLSRAYREAKGDIVWIIDCNIWMAKGVLGRMVDKLMGYRVGGAAKPYKFVHQLPIVVDLMDFSTSLAAEGRSLLDASPEEDHPTEDLGAEEFPKVMSHGGGRIDEMFMTTSHAKFYSAINTLRAAPCAVGKSNMFRKSQLDQATDAILNPKLDQSKNLPTGVDYFSHNICEDHLIGEALWTTDFPGYKSHGLVWGDIAVQPVSGMSVQAYTARRSRWLRARKYTVLSATILEPFTECFLFATYMSLAMTTIPVLSQNLGIPKTWNATAIAWFTITTLWMLIDYIGYLRLHSGVTMEVDEHTPYFAKGFKNTGGIKRRPFLEFLAAWIGREGLAFPVWAYAVVFGNTVNWRGRLFYIHWDTT
