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UGCG
Homo sapiens · Ceramide glucosyltransferase (EC 2.4.1.80)
GT21Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT21 · CAZy entry |
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| Gene symbol | UGCG |
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| Synonyms / alternate names | - GLCT-1
- Glucosylceramide synthase
- Glycosylceramide synthase
- UDP-glucose ceramide glucosyltransferase
- UDP-glucose:N-acylsphingosine D-glucosyltransferase
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| UniProt accession | Q16739 |
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| NCBI Gene ID | 7357 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Ceramide glucosyltransferase (EC 2.4.1.80) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | Interacts with RTN1; regulates the ceramide glucosyltransfer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-alpha-D-glucose
- UDP-alpha-D-xylose
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| Donor CCD code(s) | UPG, UDX |
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| Acceptor substrate(s) | - an N-acylsphing-4-enine
- N-(9Z-octadecenoyl)-sphing-4-enine
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
394 aa
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
Catalytic domain sequence
239 aa
PYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINML
