Home/GT Families/GT23/fut8
fut8
Xenopus tropicalis · Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68)
GT23Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT23 · CAZy entry |
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| Gene symbol | fut8 |
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| Synonyms / alternate names | - GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
- GDP-fucose--glycoprotein fucosyltransferase
- Glycoprotein 6-alpha-L-fucosyltransferase
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| UniProt accession | Q6NVP8 |
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| NCBI Gene ID | 407913 |
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| Source species | Xenopus tropicalis |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) |
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| Subcellular location | - Golgi apparatus
- Golgi stack membrane
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-beta-L-fucose |
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| Donor CCD code(s) | GFB |
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| Acceptor substrate(s) | N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
578 aa
MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNENPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIEQGAAAGRIRALEEQLLKAKEQIEMYKQQSSNAVSGLGKDHEILRRAIENGAKEFWYFVQSEVKKLKHLDRNELQRHVDEIIIDMGHQQRSVMTDLYYLSQTDGAGDWREREAKDLTDLVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQSWRYATGGWETVFKPVSETCTDRSGSSTGHWSGEANDKNVQVVELPIVDSLHPRPPYLPLGVPEDLADRLIRLHGDPAVWWVSQFVKYLIRPQPWLEKEIEESTKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQIDKKRVYLATDDPTLLQEAKAKYPQYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASAHFHSLDDIYYFGGQNAHNQLAIYPHQPRNAEEIPLEPGDIIGVAGNHWDGYSKGINRKLGRTGLYPSYKVKEKIETVKYPTYQEAEK
Catalytic domain sequence
500 aa
RPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNENPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIEQGAAAGRIRALEEQLLKAKEQIEMYKQQSSNAVSGLGKDHEILRRAIENGAKEFWYFVQSEVKKLKHLDRNELQRHVDEIIIDMGHQQRSVMTDLYYLSQTDGAGDWREREAKDLTDLVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQSWRYATGGWETVFKPVSETCTDRSGSSTGHWSGEANDKNVQVVELPIVDSLHPRPPYLPLGVPEDLADRLIRLHGDPAVWWVSQFVKYLIRPQPWLEKEIEESTKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQIDKKRVYLATDDPTLLQEAKAKYPQYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASAHFHSLDDIYY
