Home/GT Families/GT24/Uggt
Uggt
Drosophila melanogaster · UDP-glucose:glycoprotein glucosyltransferase (EC 2.4.1.-)
GT24Model organism · annotation ≥ 4Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT24 · CAZy entry |
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| Gene symbol | Uggt |
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| Synonyms / alternate names | - GT
- UGGG
- Ugt
- UDP--Glc:glycoprotein glucosyltransferase
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| UniProt accession | Q09332 |
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| NCBI Gene ID | 40055 |
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| Source species | Drosophila melanogaster |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | UDP-glucose:glycoprotein glucosyltransferase (EC 2.4.1.-) |
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| Subcellular location | - Endoplasmic reticulum lumen
- Endoplasmic reticulum-Golgi intermediate compartment
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Ca2+, Mn2+) |
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| Oligomeric state | monomer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucose |
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| Donor CCD code(s) | UPG |
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| Acceptor substrate(s) | N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
1548 aa
MLRAVALCVSVVLIALYTPTSGESSQSYPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDYVSGVTKLDTVLNEYDTESQQYNAALELVKSHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSSGSCQSFTFAQVGSELACSFNELQKKLEVPLAKDSLDASVVTYSFDHIFPGSENNTRTVVLYGDLGSSQFRTYHKLLEKEANAGRIRYILRHQLAKKDKRPVRLSGYGVELHLKSTEYKSQDDAPKPEAGSTSDEDLANESDVQGFDFKVLKQKHPTLKRALDQLRQRLLQGNDEIAQLKAWEFQDLGLQAAAAIAEIQGDETLQILQYTAHNFPMLARTLLAHKVTDGLRAEVKHNTEAFGRSLNVAPPDGALFINGLFFDADTMDLYSLIETLRSEMRVLESLHSNNVRGSLASSLLALDLTASSKKEFAIDIRDTAVQWVNDIENDVQYRRWPSSVMDLLRPTFPGMLRNIRKNVFNLVLVVDALQPTARSVIKLSESFVIHQAPIRLGLVFDARDANEDNLADYVAITCAYNYVSQKKDARAALSFLTDIYAAVGETKVVTKKDIVKQLTKEFTSLSFAKAEEFLEEDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGVPMPSNVVTADSDFEEAIFTEIMTHTSNLQKAVYKGELTDNDVAIDYLMNQPHVMPRLNQRILSQEDVKYLDINGVAYKNLGNVGVLNRLSNRDMTATLMDNLKYFGGKKSTELIGRASLQFLTIWVFADLETDQGRDLLTHALDYVQSGESVRVAFIPNTESSSASSRRNLNRLVWAAMQSLPPTQATEQVLKWLKKPKEKIEIPTQLEDILGSTELHLKMLRVYSQRVLGLNKSQRLVIGNGRLYGPLSSDESFDSADFALLARFSSLQYSDKVRQVLKESAQDVNEEFNSDTLLKLYASLLPRQTKTRFKLPTDLKTDHSVVKLPPKQENLPHFDVAAVLDPASRAAQKLTPILILLRQVLNCQLNLYLIPVPQHSDMPVKNFYRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLLTQQLQVPENWLVEAVRAVYDLDNIKLTDIGGPVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLGTQSQPTLVDTIVMANLGYFQLKANPGAWSLRLREGKSADIYAISHIEGTNTHHSAGSSEVQVLITSLRSHVVKLRVSKKPGMQQAELLSDDNEQAAQSGMWNSIASSFGGGSANQAATDEDTETINIFSVASGHLYERLLRIMMVSLLKHTKSPVKFWFLKNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLNVRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRRYHISALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQTWCSDSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAELKTLMSRIEDHENSHSRDSAVDDSVDDSVEVTTVTPSHEPKHGEL
Catalytic domain sequence
264 aa
INIFSVASGHLYERLLRIMMVSLLKHTKSPVKFWFLKNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLNVRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRRYHISALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQTWCSDSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAE
