COLGALT1 (GT25)

COLGALT1

Homo sapiens · Procollagen galactosyltransferase 1 (EC 2.4.1.50)

GT25Model organism · annotation ≥ 4Fold GT-AInverting10 PDB structure(s)

External resources

UniProt Q8NBJ5 AlphaFold model InterPro domains NCBI Gene 79709 CAZy GT25 PDB 8ZGC PDB 8ZGE PDB 8ZGG PDB 8ZGH PDB 9EVJ PDB 9EVK PDB 9EVL PDB 9U7H

Identification and annotation

CAZy family	GT25 · CAZy entry
Gene symbol	COLGALT1
Synonyms / alternate names	GLT25D1 Collagen beta(1-O)galactosyltransferase 1 Glycosyltransferase 25 family member 1 Hydroxylysine galactosyltransferase 1
UniProt accession	`Q8NBJ5`
NCBI Gene ID	`79709`
Source species	Homo sapiens
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Procollagen galactosyltransferase 1 (EC 2.4.1.50)
Subcellular location	Endoplasmic reticulum lumen

Structure and mechanism

Fold type	GT-A
Catalytic mechanism	Inverting
Cation dependence	No
Oligomeric state	not curated
PDB structures	`8ZGC`, `8ZGE`, `8ZGG`, `8ZGH`, `9EVJ`, `9EVK`, `9EVL`, `9U7H`, `9U7I`, `9U7J`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-alpha-D-galactose
Donor CCD code(s)	`GDU`
Acceptor substrate(s)	(5R)-5-hydroxy-L-lysyl-[collagen]
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

622 aa

MAAAPRAGRRRGQPLLALLLLLLAPLPPGAPPGADAYFPEERWSPESPLQAPRVLIALLARNAAHALPTTLGALERLRHPRERTALWVATDHNMDNTSTVLREWLVAVKSLYHSVEWRPAEEPRSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILFVDADNLILNPDTLSLLIAENKTVVAPMLDSRAAYSNFWCGMTSQGYYKRTPAYIPIRKRDRRGCFAVPMVHSTFLIDLRKAASRNLAFYPPHPDYTWSFDDIIVFAFSCKQAEVQMYVCNKEEYGFLPVPLRAHSTLQDEAESFMHVQLEVMVKHPPAEPSRFISAPTKTPDKMGFDEVFMINLRRRQDRRERMLRALQAQEIECRLVEAVDGKAMNTSQVEALGIQMLPGYRDPYHGRPLTKGELGCFLSHYNIWKEVVDRGLQKSLVFEDDLRFEIFFKRRLMNLMRDVEREGLDWDLIYVGRKRMQVEHPEKAVPRVRNLVEADYSYWTLAYVISLQGARKLLAAEPLSKMLPVDEFLPVMFDKHPVSEYKAHFSLRNLHAFSVEPLLIYPTHYTGDDGYVSDTETSVVWNNEHVKTDWDRAKSQKMREQQALSREAKNSDVLQSPLDSAARDEL

Catalytic domain sequence

239 aa

VLIALLARNAAHALPTTLGALERLRHPRERTALWVATDHNMDNTSTVLREWLVAVKSLYHSVEWRPAEEPRSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILFVDADNLILNPDTLSLLIAENKTVVAPMLDSRAAYSNFWCGMTSQGYYKRTPAYIPIRKRDRRGCFAVPMVHSTFLIDLRKAASRNLAFYPPHPDYTWSFDDIIVFAFSCKQAEVQMYVCNKEEYGFLP