Home/GT Families/GT29/ST3GAL6
ST3GAL6
Homo sapiens · Type 2 lactosamine alpha-2,3-sialyltransferase (EC 2.4.3.6)
GT29Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
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| Gene symbol | ST3GAL6 |
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| Synonyms / alternate names | - SIAT10
- CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
- ST3Gal VI
- Sialyltransferase 10
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| UniProt accession | Q9Y274 |
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| NCBI Gene ID | 10402 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Type 2 lactosamine alpha-2,3-sialyltransferase (EC 2.4.3.6) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
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| Donor CCD code(s) | NCC |
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| Acceptor substrate(s) | - a neolactoside nLc4Cer(d18:1(4E))
- a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative
- a neolactoside nLc6Cer(d18:1(4E))
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
331 aa
MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLLRFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNLVINLTQD
Catalytic domain sequence
256 aa
DFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKN
