Home/GT Families/GT29/ST6GAL1
ST6GAL1
Gallus gallus · Beta-galactoside alpha-2,6-sialyltransferase 1 (EC 2.4.3.1)
GT29Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
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| Gene symbol | ST6GAL1 |
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| Synonyms / alternate names | - SIAT1
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
- ST6Gal I
- Sialyltransferase 1
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| UniProt accession | Q92182 |
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| NCBI Gene ID | 396169 |
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| Source species | Gallus gallus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta-galactoside alpha-2,6-sialyltransferase 1 (EC 2.4.3.1) |
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| Subcellular location | - Golgi apparatus, Golgi stack membrane
- Secreted
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | monomer |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
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| Donor CCD code(s) | NCC |
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| Acceptor substrate(s) | a beta-D-galactoside |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
413 aa
MVHINVLKKFMCVLVVILIALTVCLWKETRGSYYVPLKNDGTQVHRALDKWNLLKSQGLLHEAAGEMGQMPKALPNNQNKVKGITSGAVEKSRKAAEHVKVWDKDSSSRNLIPRLQKVRKNYLSMNKYNVTYNGKMNAAKLSPEQLLCRLRDRVNVTMIRGSDGPFNSSEWQHYLPDKSLNETVGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYILNPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHPLLFEKNLVKHLNQGTDEDIYTHGKVTLPGFRNVHC
Catalytic domain sequence
209 aa
TVGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYILNPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHPLLFEKNLVKHLNQ
