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Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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ST6GAL1

Sus scrofa · Beta-galactoside alpha-2,6-sialyltransferase 1 (EC 2.4.3.1)

GT29Non-model organism · annotation 4–5Fold GT-AInverting

External resources

UniProt V9I1H7AlphaFold modelInterPro domainsCAZy GT29

Identification and annotation

CAZy familyGT29 · CAZy entry
Gene symbolST6GAL1
Synonyms / alternate names
  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
  • ST6Gal I
  • Sialyltransferase 1
UniProt accessionV9I1H7
NCBI Gene IDnot curated
Source speciesSus scrofa
Taxonomic domainEukaryota
UniProt annotation level4

Function and localisation

Enzyme functionBeta-galactoside alpha-2,6-sialyltransferase 1 (EC 2.4.3.1)
Subcellular location
  • Golgi apparatus, Golgi stack membrane
  • Secreted

Structure and mechanism

Fold typeGT-A
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorCMP-N-acetyl-beta-neuraminate
Donor CCD code(s)NCC
Acceptor substrate(s)
  • a beta-D-galactoside
  • an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

408 aa 
MIHTSLKKKFSCCLLVFLLFAIICVWKEKKKGSYYESLTLQTKEPQVLRSLEKLTPGSGSQSASSSGTQNAQRGSQALGSPSSPAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGVKYSAEALLCHLRDNVNVSMVEATDFPFNTSEWEGYLPKENIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHEAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEQRFLKDSLYGEGILVVWDPSIYHSDIPKWYKNPDYRFFDNFKSYRKLHPDQPFYILKPQMPWELWDIIQEISPEAIQPNPPSSGMLGIIIMMTLCDQVDVYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLFEKNMVKHLNRGPDEDIYLLGKATLPGFRSIHCGA

Catalytic domain sequence

265 aa 
AEALLCHLRDNVNVSMVEATDFPFNTSEWEGYLPKENIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHEAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEQRFLKDSLYGEGILVVWDPSIYHSDIPKWYKNPDYRFFDNFKSYRKLHPDQPFYILKPQMPWELWDIIQEISPEAIQPNPPSSGMLGIIIMMTLCDQVDVYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLFEKNMVKHLNRGPDEDIYLLGKATLPGF
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