Home/GT Families/GT29/St3gal1
St3gal1
Mus musculus · CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (EC 2.4.3.2; 2.4.3.4)
GT29Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
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| Gene symbol | St3gal1 |
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| Synonyms / alternate names | - Gal-NAc6S
- Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
- Monosialoganglioside sialyltransferase
- ST3Gal I
- ST3GalA.1
- ST3O
- Sialyltransferase 4A
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| UniProt accession | Q544T4 |
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| NCBI Gene ID | 20442 |
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| Source species | Mus musculus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (EC 2.4.3.2; 2.4.3.4) |
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| Subcellular location | - Golgi apparatus, Golgi stack membrane
- Golgi apparatus, trans-Golgi network membrane
- Secreted
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
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| Donor CCD code(s) | NCC |
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| Acceptor substrate(s) | - a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]
- a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]
- a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative
- a ganglioside GA1 (d18:1(4E))
- a ganglioside GA1
- a ganglioside GD1b
- a ganglioside GM1 (d18:1(4E))
- ganglioside GM1 (d18:1(4E)/18:0)
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
337 aa
MRRKTLKYLTFFLLFIFLTSFVLNYSNTGVPSAWFPKQMLLELSENFRRFIKSQPCTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVGCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVISATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFKGR
Catalytic domain sequence
244 aa
TVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVGCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVISATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDGDFEYNITTTLAA
