Home/GT Families/GT29/st3gal7
st3gal7
Danio rerio · Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9)
GT29Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
|---|
| Gene symbol | st3gal7 |
|---|
| Synonyms / alternate names | - st3gal5l
- zgc:153853
- CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
- Ganglioside GM3 synthase
- ST3Gal V
- Sialyltransferase 9
|
|---|
| UniProt accession | Q08BF4 |
|---|
| NCBI Gene ID | 554166 |
|---|
| Source species | Danio rerio |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 4 |
|---|
Function and localisation
| Enzyme function | Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9) |
|---|
| Subcellular location | Golgi apparatus membrane |
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | No |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
|---|
| Donor CCD code(s) | NCC |
|---|
| Acceptor substrate(s) | - a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
- a beta-D-Gal-(1<->1')-ceramide
- ganglioside GA1 (d18:1(4E)/18:0)
- ganglioside GA2 (d18:1(4E)/18:0)
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
382 aa
MVTLKHLSVNDNDEDGVPLLPEASSLESPTTQHSRAESRDFFLSRRYNFIVSIVLLLSLYSALLVPAYLPTAEPIWTNESSAENLALLNQSASLLSQSCHSGWSVERMRTMLSTPAGLLKIPVFLENGTGDWALPPPLGLQGSEEMAEQALKALPFTAVPTGPETCRRCVVVGSGGILHGKNLGAHIDQYNIIIRVNNAPVFGFESDAGSRTTIRLIYPEGAPSHIQEYERTEVVALVVFKSLDLAWMTSVVTKEPLSWWSKLWFWKDVIDSIPLQPENVRILNPEIMYRTGQVLQTYAEQQRKMVPTLGITAVVVALQVCDEVSIAGFGYDLQHPGAPLHYYGSLRMDAMKTQVVHDVSAETVFLKELVKAGAVRDLTGAL
Catalytic domain sequence
239 aa
PPPLGLQGSEEMAEQALKALPFTAVPTGPETCRRCVVVGSGGILHGKNLGAHIDQYNIIIRVNNAPVFGFESDAGSRTTIRLIYPEGAPSHIQEYERTEVVALVVFKSLDLAWMTSVVTKEPLSWWSKLWFWKDVIDSIPLQPENVRILNPEIMYRTGQVLQTYAEQQRKMVPTLGITAVVVALQVCDEVSIAGFGYDLQHPGAPLHYYGSLRMDAMKTQVVHDVSAETVFLKELVKAG
