Home/GT Families/GT29/st8sia1
st8sia1
Xenopus laevis · Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8)
GT29Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT29 · CAZy entry |
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| Gene symbol | st8sia1 |
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| Synonyms / alternate names | - siat8a
- Alpha-2,8-sialyltransferase 8A
- Ganglioside GD3 synthase
- Sialyltransferase 8A
- Sialyltransferase St8Sia I
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| UniProt accession | Q6ZXA0 |
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| NCBI Gene ID | 398735 |
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| Source species | Xenopus laevis |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
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| Donor CCD code(s) | NCC |
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| Acceptor substrate(s) | - an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative
- a ganglioside GM3 (d18:1(4E))
- a ganglioside GD3 (d18:1(4E))
- a ganglioside GD1a (d18:1(4E))
- a ganglioside GT1b (d18:1(4E))
- a ganglioside GM1b (d18:1(4E))
- a ganglioside GD3
- [alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
359 aa
MWGRWRGAGGRRGVAQPVIPQMKLLGGRVPLGASALGLLIVCWFYIFPGGERLPGHKEMIRQVLQFGPRWGRNRSSGDSFRKLLQDCCDPPRLFSMTKANTALGENLWYDGEFFQSLTIDNTTRSLFPQDTPIKLPLKRCSVVGNGGILKNSRCGEQIDEADFVMRCNLPPLSREYTDDVGTKTQLVTVNPSIIDKRFQNLLWSRKSFVESVSVYKQSYVYMPAFSTKRGTDPSLRVYYTLEDFGTNQTVLFANPNFLRNVGKFWKSKGVHSKRLSTGLFMVSAALSLCEEVTIYGFWPFQMDLGGRHISHHYYDNMLPLSGVHAMPEEFLQLWHLHKSGVLQMQLDQCKKDVSSKKPH
Catalytic domain sequence
246 aa
MTKANTALGENLWYDGEFFQSLTIDNTTRSLFPQDTPIKLPLKRCSVVGNGGILKNSRCGEQIDEADFVMRCNLPPLSREYTDDVGTKTQLVTVNPSIIDKRFQNLLWSRKSFVESVSVYKQSYVYMPAFSTKRGTDPSLRVYYTLEDFGTNQTVLFANPNFLRNVGKFWKSKGVHSKRLSTGLFMVSAALSLCEEVTIYGFWPFQMDLGGRHISHHYYDNMLPLSGVHAMPEEFLQLWHLHKSGV
