GYS1 (GT3)

GYS1

Homo sapiens · Glycogen [starch] synthase, muscle (EC 2.4.1.11)

GT3Model organism · annotation ≥ 4Fold GT-BRetaining9 PDB structure(s)

External resources

UniProt P13807 AlphaFold model InterPro domains NCBI Gene 2997 CAZy GT3 PDB 7Q0B PDB 7Q0S PDB 7Q12 PDB 7Q13 PDB 7ZBN PDB 8CVX PDB 8CVY PDB 8CVZ

Identification and annotation

CAZy family	GT3 · CAZy entry
Gene symbol	GYS1
Synonyms / alternate names	GYS Glycogen synthase 1
UniProt accession	`P13807`
NCBI Gene ID	`2997`
Source species	Homo sapiens
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Glycogen [starch] synthase, muscle (EC 2.4.1.11)
Subcellular location	not curated

Structure and mechanism

Fold type	GT-B
Catalytic mechanism	Retaining
Cation dependence	No
Oligomeric state	tetramer
PDB structures	`7Q0B`, `7Q0S`, `7Q12`, `7Q13`, `7ZBN`, `8CVX`, `8CVY`, `8CVZ`, `8Z0A`

Donor and acceptor specificity

Sugar nucleotide donor	UDP-alpha-D-glucose
Donor CCD code(s)	`UPG`
Acceptor substrate(s)	[(1->4)-alpha-D-glucosyl](n)
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

737 aa

MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN

Catalytic domain sequence

573 aa

WEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYM