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Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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PYGM

Oryctolagus cuniculus · Glycogen phosphorylase, muscle form (EC 2.4.1.1)

GT35Non-model organism · annotation 4–5Fold GT-BRetaining230 PDB structure(s)

External resources

UniProt P00489AlphaFold modelInterPro domainsNCBI Gene 100008972CAZy GT35PDB 1A8IPDB 1ABBPDB 1AXRPDB 1B4DPDB 1BX3PDB 1C50PDB 1C8KPDB 1C8L

Identification and annotation

CAZy familyGT35 · CAZy entry
Gene symbolPYGM
Synonyms / alternate namesMyophosphorylase
UniProt accessionP00489
NCBI Gene ID100008972
Source speciesOryctolagus cuniculus
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionGlycogen phosphorylase, muscle form (EC 2.4.1.1)
Subcellular locationnot curated

Structure and mechanism

Fold typeGT-B
Catalytic mechanismRetaining
Cation dependenceNo
Oligomeric statehomodimer
PDB structures1A8I, 1ABB, 1AXR, 1B4D, 1BX3, 1C50, 1C8K, 1C8L, 1E1Y, 1FS4, 1FTQ, 1FTW, 1FTY, 1FU4, 1FU7, 1FU8, 1GFZ, 1GG8, 1GGN, 1GPA, 1GPB, 1GPY, 1H5U, 1HLF, 1K06, 1K08, 1KTI, 1LWN, 1LWO, 1NOI, 1NOJ, 1NOK, 1P29, 1P2B, 1P2D, 1P2G, 1P4G, 1P4H, 1P4J, 1PYG, 1UZU, 1WUT, 1WUY, 1WV0, 1WV1, 1WW2, 1WW3, 1XC7, 1XKX, 1XL0, 1XL1, 1Z62, 1Z6P, 1Z6Q, 2AMV, 2F3P, 2F3Q, 2F3S, 2F3U, 2FET, 2FF5, 2FFR, 2G9Q, 2G9R, 2G9U, 2G9V, 2GJ4, 2GM9, 2GPA, 2GPB, 2GPN, 2IEG, 2IEI, 2OFF, 2PRI, 2PRJ, 2PYD, 2PYI, 2QLM, 2QLN, 2QN1, 2QN2, 2QN3, 2QN7, 2QN8, 2QN9, 2QNB, 2QRG, 2QRH, 2QRM, 2QRP, 2QRQ, 2SKC, 2SKD, 2SKE, 3AMV, 3BCR, 3BCS, 3BCU, 3BD6, 3BD7, 3BD8, 3BDA, 3CUT, 3CUU, 3CUV, 3CUW, 3E3L, 3E3N, 3E3O, 3EBO, 3EBP, 3G2H, 3G2I, 3G2J, 3G2K, 3G2L, 3G2N, 3GPB, 3L79, 3L7A, 3L7B, 3L7C, 3L7D, 3MQF, 3MRT, 3MRV, 3MRX, 3MS2, 3MS4, 3MS7, 3MSC, 3MT7, 3MT8, 3MT9, 3MTA, 3MTB, 3MTD, 3NC4, 3NP7, 3NP9, 3NPA, 3S0J, 3SYM, 3SYR, 3T3D, 3T3E, 3T3G, 3T3H, 3T3I, 3ZCP, 3ZCQ, 3ZCR, 3ZCS, 3ZCT, 3ZCU, 3ZCV, 4CTM, 4CTN, 4CTO, 4EJ2, 4EKE, 4EKY, 4EL0, 4EL5, 4GPB, 4MHO, 4MHS, 4MI3, 4MI6, 4MI9, 4MIC, 4MRA, 4YI3, 4YI5, 4YUA, 4Z5X, 5GPB, 5JTT, 5JTU, 5LRC, 5LRD, 5LRE, 5LRF, 5MCB, 5MEM, 5O50, 5O52, 5O54, 5O56, 5OWY, 5OWZ, 5OX0, 5OX1, 5OX3, 5OX4, 6F3J, 6F3L, 6F3R, 6F3S, 6F3U, 6GPB, 6QA6, 6QA7, 6QA8, 6R0H, 6R0I, 6S4H, 6S4K, 6S4O, 6S4P, 6S4R, 6S51, 6S52, 6Y55, 6Y5C, 6Y5O, 6YVE, 7GPB, 7ONF, 7P7D, 7Q5I, 8BZS, 8GPB, 8QMU, 8R52, 8R53, 8R6V, 9FRM, 9GPB

Donor and acceptor specificity

Sugar nucleotide donornot curated
Donor CCD code(s)not curated
Acceptor substrate(s)
  • [(1->4)-alpha-D-glucosyl](n)
  • phosphate
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

843 aa 
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKIP

Catalytic domain sequence

800 aa 
KKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGV
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