Home/GT Families/GT48/FKS1
FKS1
Cryptococcus neoformans (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) · 1,3-beta-glucan synthase component FKS1 (EC 2.4.1.34)
GT48Non-model organism · annotation 4–5Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT48 · CAZy entry |
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| Gene symbol | FKS1 |
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| Synonyms / alternate names | not curated |
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| UniProt accession | O93927 |
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| NCBI Gene ID | 23889702 |
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| Source species | Cryptococcus neoformans (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | 1,3-beta-glucan synthase component FKS1 (EC 2.4.1.34) |
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| Subcellular location | Cell membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | Component of the 1,3-beta-glucan synthase (GS) complex compo |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-glucose |
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| Donor CCD code(s) | UPG |
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| Acceptor substrate(s) | [(1->3)-beta-D-glucosyl](n) |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
1799 aa
MSYPNPPPPPKGSASFSSSSSDPFNQTNQLPYDSQFPPQHAFAHPSAPNPGAGGAGVAPPGQGGQYAPYYDNEPEMGGRWEGGGMGRETWASESGWSQNEPNYPPSDYHGGPGYLPSRASTPTFEGSNAGHRPRDPYPAWTVDANIPLSKEEIEDVLIDLANKFGFQKDSSRNVYDFLMIQLDSRASRMSPNQALLTLHADYIGGEHANYRKWYFAAQLDLDDAIGAVQNPGLNRVRSVARRGGKTKNPLATAQEKSLESATSRWRTAMNNMSQYDRLRQVALYLLCWGEAAQVRFMPECLCFIFKCADDYYRSPECQNRQEAVPEGLYLRAVIKPLYRFLRDQGYEVVDGKFLRRERDHDKVIGYDDVNQLFWYPEGISRITLNDNTRLVDIPPAQRFMKFDRIDWNKVFFKTYLEKRSFFHLLVNFNRIWVLHISVFWFFTAYNAPSIYAPSGSTTATTPMAWSMTGLGGFVATLIMIAATLAEFSYIPTTWNNTSHLTRRLIFLLIILAITGGPSIYIAFFNQTGHVALILGIVQFFCSVVATIAFATLPSGRMFGDRVAGKSRKYLANQTFTASYPALGFYPRVASFLLWFLVFGCKFTESYFFLTLSFRDPMKVMNGMKVQNCHDKYFGNGLCTNQPAFALAVMFVMDLTLFFLDTFLWYVIWNTVFSIARSFAIGMSIWTPWKDIFARLPKRIYAKILATDDMEVKYKPKVLVSQVWNAVIISMYREHLLSIEHVQKLLYHQIQSDQPGKRTLRAPAFFISQSEKGSKAEFFPKGSEAERRICFFAQSLTTSIPAPIPVDAMPTFTVLVPHYSEKILLSLREIIREEDQNTRVTLLEYLKQLHPVEWDNFVRDTKILAEESDAFNGGNPFASDEKEEAKKADDIPFYTIGFKSAAPEYTLRTRIWASLRAQTLYRTVSGFMNYSKAIKLLYRVENPEVVQLFGGNTDQLERELERMARRKFKFVVSMQRYSKFNKEEHENAEFLLRAYPDLQIAYLDEEPPRKDGGESRIFSALIDGHSEIMPNGRRRPKFRIELPGNPILGDGKSDNQNHAIVFYRGEYLQLIDANQDNYLEECLKIRNVLGEFEEFKVSTQSPYAAQGHADFAKFPVAILGAREYIFSENIGILGDIAAGKEQTFGTLAARSLSYIGGKLHYGHPDFLNAIYMNTRGGVSKAQKGLHLNEDIFAGMLAFGRGGRIKHSEYYQCGKGRDLGFGTILNFQTKIGTGMGEQMLSREYYYLGTQLPIDRFLTFYYGHPGFHINNILVMMSVQVFMLALVFLGTLNKQLTVCRYSSGGDILPGQSGCYNLVPVFKWIKRCIISIFIVFWIAFVPLFVQELTERGTGRAILRLCKHFLSLSPVFEVFSTQIYMHSILNDLTFGGARYIATGRGFATTRISFSILYSRFAGPSIYLGMRTLVLLLFITLTVWVPHLIYFWITVVGLCVAPFLFNPHQFAIADFIIDYREFLRWMSRGNSRTHANSWVGYCRLSRTRVTGFKRKRLGLPSEKLSSDVPRAPWKAILIGEIIGPICLAILFVICYLFIKSFAVDGQIQPGLVRIAIIALGPIVWNMALLITLFLISVFLGPCLNSYTHQFGATMAALAHFGAVAGMLVFFELLWFLELWNTSHAVLGIIAVISVQRCIFKFLIAVFLSREFKHDETNRAWWTGVWFNRGLGSHALSQPAREFVVKTIEMGLYSADFIACHLLLALLTIPMFIPYFDRVHATMLFWLAPNQQIRPPIYSFRQRSQRRKIVFKYGLLYLIIQGIFIALIVVPIIFKDVAGLTPKSVPFNGII
Catalytic domain sequence
815 aa
FFPKGSEAERRICFFAQSLTTSIPAPIPVDAMPTFTVLVPHYSEKILLSLREIIREEDQNTRVTLLEYLKQLHPVEWDNFVRDTKILAEESDAFNGGNPFASDEKEEAKKADDIPFYTIGFKSAAPEYTLRTRIWASLRAQTLYRTVSGFMNYSKAIKLLYRVENPEVVQLFGGNTDQLERELERMARRKFKFVVSMQRYSKFNKEEHENAEFLLRAYPDLQIAYLDEEPPRKDGGESRIFSALIDGHSEIMPNGRRRPKFRIELPGNPILGDGKSDNQNHAIVFYRGEYLQLIDANQDNYLEECLKIRNVLGEFEEFKVSTQSPYAAQGHADFAKFPVAILGAREYIFSENIGILGDIAAGKEQTFGTLAARSLSYIGGKLHYGHPDFLNAIYMNTRGGVSKAQKGLHLNEDIFAGMLAFGRGGRIKHSEYYQCGKGRDLGFGTILNFQTKIGTGMGEQMLSREYYYLGTQLPIDRFLTFYYGHPGFHINNILVMMSVQVFMLALVFLGTLNKQLTVCRYSSGGDILPGQSGCYNLVPVFKWIKRCIISIFIVFWIAFVPLFVQELTERGTGRAILRLCKHFLSLSPVFEVFSTQIYMHSILNDLTFGGARYIATGRGFATTRISFSILYSRFAGPSIYLGMRTLVLLLFITLTVWVPHLIYFWITVVGLCVAPFLFNPHQFAIADFIIDYREFLRWMSRGNSRTHANSWVGYCRLSRTRVTGFKRKRLGLPSEKLSSDVPRAPWKAILIGEIIGPICLAILFVICYLFIKSFAVDGQIQPGLVRIAIIALGPIVWNMALLITLFLISVFLGPC
