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large2
Danio rerio · Xylosyl- and glucuronyltransferase LARGE2s (EC 2.4.-.-)
GT49Model organism · annotation ≥ 4Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT49 · CAZy entry |
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| Gene symbol | large2 |
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| Synonyms / alternate names | - gyltl1b
- Glycosyltransferase-like 1B
- LARGE xylosyl- and glucuronyltransferase 2
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| UniProt accession | Q66PG1 |
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| NCBI Gene ID | 446214 |
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| Source species | Danio rerio |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Xylosyl- and glucuronyltransferase LARGE2s (EC 2.4.-.-) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-alpha-D-xylose
- UDP-alpha-D-glucuronate
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| Donor CCD code(s) | UDX, UGA |
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| Acceptor substrate(s) | - 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein]
- 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]
- 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
750 aa
MLCPCRGKLKLLVVSLSFVILFTWLYLLVGNSENGRSLLLSACLVESTEARLLERDVLASRVREVEEENRQIRLQLSQSQGLAGQPAEGNYGNQQWVASADTGPEDVENTAEERANHSECSRSPTAEKCELLHVACVCAGHNASRDVVTLVKSILFHRRNPLHFHFITDTVANQILSTLFQSWMVPSVQVSFYDADELKSEVSWIPNKHYSGIYGLMKLTLTKALPSNLSKVIVLDTDITFATDIAELWAIFRKFTEKQVIGLVENQSDWYLGNLWKNHKPWPALGRGFNTGVILLYLERLRRMGWEQMWRLTAERELMSMLSTSLADQDIFNAFIKQNPVLVHQLPCFWNVQLSDHTRSEQCYTEVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSQASSESTVLQQALEELDEDDQCYDFRRERIMLHRVHLYFLQYEYSPTDDGTDITLVAQLSMDRLQMLEAICKHWEGPISLALYMSDAEAQQFLRYAQASEVLKNRKNVGYHIVYKEGQFYPVNLVRNVALRNVNTPYVFLTDVDFLPMYGLYDYLRKSIVQLDMANTKKALVVPAFETLRYRLSFPKSKAELLSMLDMGTLYTFRYHVWTKGHAPTNYAKWRTATTPYKVEWEADFEPYVVVRRDCPEYDQRFVGFGWNKVSHIMELDAQEYDLIVLPNAFMIHMPHAPSFDISKFRSSPSYRYCLTTLKDEFHQDLSRKYGSAALKYLTAQRNI
Catalytic domain sequence
280 aa
LHVACVCAGHNASRDVVTLVKSILFHRRNPLHFHFITDTVANQILSTLFQSWMVPSVQVSFYDADELKSEVSWIPNKHYSGIYGLMKLTLTKALPSNLSKVIVLDTDITFATDIAELWAIFRKFTEKQVIGLVENQSDWYLGNLWKNHKPWPALGRGFNTGVILLYLERLRRMGWEQMWRLTAERELMSMLSTSLADQDIFNAFIKQNPVLVHQLPCFWNVQLSDHTRSEQCYTEVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELF
