Home/GT Families/GT50/PIGM
PIGM
Homo sapiens · GPI alpha-1,4-mannosyltransferase I, catalytic subunit (EC 2.4.1.-)
GT50Model organism · annotation ≥ 4Fold GT-CInverting
External resources
Identification and annotation
| CAZy family | GT50 · CAZy entry |
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| Gene symbol | PIGM |
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| Synonyms / alternate names | - GPI mannosyltransferase I
- Phosphatidylinositol-glycan biosynthesis class M protein
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| UniProt accession | Q9H3S5 |
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| NCBI Gene ID | 93183 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | GPI alpha-1,4-mannosyltransferase I, catalytic subunit (EC 2.4.1.-) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-C |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | Part of the glycosylphosphatidylinositol-mannosyltransferase |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | not curated |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | - a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol
- a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
423 aa
MGSTKHWGEWLLNLKVAPAGVFGVAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCDLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLMLWFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTERIKYD
Catalytic domain sequence
269 aa
VSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLMLWFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQII
