mrcB (GT51)

mrcB

Escherichia coli (strain K12) · Penicillin-binding protein 1B

GT51Model organism · annotation ≥ 4Fold Lysozyme-typeInverting11 PDB structure(s)

External resources

UniProt P02919 AlphaFold model InterPro domains NCBI Gene 944843 CAZy GT51 PDB 3FWL PDB 3VMA PDB 5FGZ PDB 5HL9 PDB 5HLA PDB 5HLB PDB 5HLD PDB 6FZK

Identification and annotation

CAZy family	GT51 · CAZy entry
Gene symbol	mrcB
Synonyms / alternate names	pbpF ponB Murein polymerase
UniProt accession	`P02919`
NCBI Gene ID	`944843`
Source species	Escherichia coli (strain K12)
Taxonomic domain	Bacteria
UniProt annotation level	5

Function and localisation

Enzyme function	Penicillin-binding protein 1B
Subcellular location	not curated

Structure and mechanism

Fold type	Lysozyme-type
Catalytic mechanism	Inverting
Cation dependence	No
Oligomeric state	monomer
PDB structures	`3FWL`, `3VMA`, `5FGZ`, `5HL9`, `5HLA`, `5HLB`, `5HLD`, `6FZK`, `6G5R`, `6YN0`, `7LQ6`

Donor and acceptor specificity

Sugar nucleotide donor	not curated
Donor CCD code(s)	not curated
Acceptor substrate(s)	[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

844 aa

MAGNDREPIGRKGKPTRPVKQKVSRRRYEDDDDYDDYDDYEDEEPMPRKGKGKGKGRKPRGKRGWLWLLLKLAIVFAVLIAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMTISKNEMVKLLEATQYRQVSKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRARLTFDGDHLATIVNMENNRQFGFFRLDPRLITMISSPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQQIIDQELYDMLSARPLGVQPRGGVISPQPAFMQLVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAAVEGIPALKKQRKLSDLETAIVVVDRFSGEVRAMVGGSEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPKIYRLNTWIADAPIALRQPNGQVWSPQNDDRRYSESGRVMLVDALTRSMNVPTVNLGMALGLPAVTETWIKLGVPKDQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSFPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPNLHLAGKTGTTNNNVDTWFAGIDGSTVTITWVGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLNLVPPEDIADMGVDYDGNFVCSGGMRILPVWTSDPQSLCQQSEMQQQPSGNPFDQSSQPQQQPQQQPAQQEQKDSDGVAGWIKDMFGSN

Catalytic domain sequence

171 aa

NGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRL