pbpA (GT51)

pbpA

Streptococcus pneumoniae (strain ATCC BAA-255 / R6) · Penicillin-binding protein 1A

GT51Non-model organism · annotation 4–5Fold Lysozyme-typeInverting5 PDB structure(s)

External resources

UniProt Q8DR59 AlphaFold model InterPro domains CAZy GT51 PDB 2C5W PDB 2C6W PDB 2V2F PDB 2ZC5 PDB 2ZC6

Identification and annotation

CAZy family	GT51 · CAZy entry
Gene symbol	pbpA
Synonyms / alternate names	exp2 ponA Exported protein 2
UniProt accession	`Q8DR59`
NCBI Gene ID	not curated
Source species	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic domain	Bacteria
UniProt annotation level	5

Function and localisation

Enzyme function	Penicillin-binding protein 1A
Subcellular location	not curated

Structure and mechanism

Fold type	Lysozyme-type
Catalytic mechanism	Inverting
Cation dependence	No
Oligomeric state	Interacts with MreC in the elongasome
PDB structures	`2C5W`, `2C6W`, `2V2F`, `2ZC5`, `2ZC6`

Donor and acceptor specificity

Sugar nucleotide donor	not curated
Donor CCD code(s)	not curated
Acceptor substrate(s)	[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

719 aa

MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQGGSALTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQGYISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQAVETNRDWGSTMKPITDYAPALEYGVYESTATIVHDEPYNYPGTNTPVYNWDRGYFGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLSYGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPAPQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP

Catalytic domain sequence

177 aa

QLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQGGSALTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMK