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Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58) · N-acetyllactosaminide alpha-2,3-sialyltransferase (EC 2.4.3.6)
GT52Non-model organism · annotation 4–5Fold GT-AInverting4 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT52 · CAZy entry |
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| Gene symbol | lst |
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| Synonyms / alternate names | - CMP-N-acetylneuraminate:beta-galactoside alpha-2,3-sialyltransferase
- Lipooligosaccharide sialyltransferase
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| UniProt accession | P72097 |
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| NCBI Gene ID | not curated |
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| Source species | Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | N-acetyllactosaminide alpha-2,3-sialyltransferase (EC 2.4.3.6) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | homodimer |
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| PDB structures | 2YK4, 2YK5, 2YK6, 2YK7 |
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Donor and acceptor specificity
| Sugar nucleotide donor | CMP-N-acetyl-beta-neuraminate |
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| Donor CCD code(s) | NCC |
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| Acceptor substrate(s) | a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
371 aa
MGLKKACLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKEKLFNEEGEPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFHLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTGNLIQSSSYLGDEFSVNGTIKRNFARMMIGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKTGDETGGTVRILLGSPDKEMKEISEKAAKNFKIQYVAPHPRQTYGLSGVTTLNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFTQSGIPILTFDDKN
Catalytic domain sequence
269 aa
ERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFHLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTGNLIQSSSYLGDEFSVNGTIKRNFARMMIGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKTGDETGGTVRILLGSPDKEMKEISEKAAKNFKIQYVAPHPRQTYGLSGVTTLNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPA
