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Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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MGAT4C

Gallus gallus · Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.201)

GT54Model organism · annotation ≥ 4Fold GT-AInverting

External resources

UniProt Q9DGD1AlphaFold modelInterPro domainsNCBI Gene 395415CAZy GT54

Identification and annotation

CAZy familyGT54 · CAZy entry
Gene symbolMGAT4C
Synonyms / alternate names
  • MGAT6
  • N-acetylglucosaminyltransferase VI
  • N-glycan branching N-acetylglucosaminyltransferase VI
UniProt accessionQ9DGD1
NCBI Gene ID395415
Source speciesGallus gallus
Taxonomic domainEukaryota
UniProt annotation level4

Function and localisation

Enzyme functionAlpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.201)
Subcellular locationGolgi apparatus membrane

Structure and mechanism

Fold typeGT-A
Catalytic mechanismInverting
Cation dependenceYes (Mn2+)
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorUDP-N-acetyl-alpha-D-glucosamine
Donor CCD code(s)UD1
Acceptor substrate(s)
  • N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
  • an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

464 aa 
MRCSPKRSLTAVIAASFLLLLLLLLLHRGSWQDPQEVQFRDLPSDAVLKILKQGSLHILQDTDNLCALHNISYHLLAGSPLPHKKFLAVGLSSVRRPRGYYLPDTLQSLFKQSSEEELQEMVVVVHLADADPIWNAQVAADISHRFAHHILLGRLVLIHTPHEFYPTLEGLKRNYNDPEERVKFRSKQNVDYAFLFTFAANLSSYYLMIEDDVWSAKSFFTAIRKAVASQEGSNWATLEFSKLGYIGKLYRSSDLPRLARFLLLFYQEMPCDWLLTHFRLLLTQKDVIRFKPSLFQHMGLYSSFQGTVNRLEDDEFQADAMDLPDNPPAALFTNMVVFENYEPSKAYSTARGYFWGKNPAVGSIFSIVFHQPARVTRVRVQTGSSERPGDFLHAGVLELGRGRRADGRDCSVYTTVGTFEKGNLEWRGLEKGMPNPVECVRIRVTQSQSEWLIIQSIGIWTAGT

Catalytic domain sequence

254 aa 
DNLCALHNISYHLLAGSPLPHKKFLAVGLSSVRRPRGYYLPDTLQSLFKQSSEEELQEMVVVVHLADADPIWNAQVAADISHRFAHHILLGRLVLIHTPHEFYPTLEGLKRNYNDPEERVKFRSKQNVDYAFLFTFAANLSSYYLMIEDDVWSAKSFFTAIRKAVASQEGSNWATLEFSKLGYIGKLYRSSDLPRLARFLLLFYQEMPCDWLLTHFRLLLTQKDVIRFKPSLFQHMGLYSSFQGTVNRLEDDEF
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